Plasticity of emesis to a 5-HT3 agonist: effect of order of visceral nerve cuts.
Plasticity of emesis to a 5-HT3 agonist: effect of order of visceral nerve cuts.
复制标题
5-HT3 激动剂呕吐的可塑性：内脏神经切断顺序的影响。
DOI：
10.1097/00001756-199404000-00033
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发表时间：
1994
期刊：
影响因子：
1.7
通讯作者：
Nonaka,S
中科院分区：
文献类型：
--
作者：
Miller,AD;Jakus,J;Nonaka,S
3 型血清素受体对于放射和癌症化疗引起的呕吐至关重要。为了研究其中的机制，我们分析了猫腹部内脏去神经术的效果。 5-羟色胺-3受体激动剂苯基双胍引起的呕吐阈值根据慢性神经横断的顺序而变化。下胸迷走神经切断术、内脏切除术及其连续组合增加了阈值。然而，内脏切除术导致阈值大幅增加，14-51天后进行迷走神经切断术，阈值平均下降40%。这些结果证明了催吐反射的可塑性和调节潜力。
SEROTONIN type 3 receptors are critical for vomiting induced by radiation and cancer chemotherapy. To investigate the mechanisms involved, we analyzed the effects of abdominal visceral denervation using cats. Thresholds for vomiting induced by the serotonin-3 receptor agonist phenylbiguanide varied depending on the order of chronic nerve transections. Lower thoracic vagotomy, splanchnicectomy, and their sequential combination increased thresholds. However, when splanchnicectomy, which causes a large increase in threshold, was followed 14–51 days later by vagotomy, thresholds dropped by an average of 40%. These results demonstrate plasticity in, and potential for modulation of, the emetic reflex.