Obesity indicators and cardiometabolic status in 4-y-old children
Obesity indicators and cardiometabolic status in 4-y-old children
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DOI：
10.3945/ajcn.2009.27547
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发表时间：
2010-01-01
影响因子：
7.1
通讯作者：
Martorell, Reynaldo
中科院分区：
文献类型：
--
作者：
Corvalan, Camila;Uauy, Ricardo;Martorell, Reynaldo
背景资料：在成年人和青少年中，肥胖与心血管疾病危险因素呈正相关;然而，在学龄前儿童中的证据很少。目的：目的是评估324名4岁智利儿童的肥胖指标与心血管代谢危险因素之间的关系。设计：我们收集了人体测量数据，并计算了肥胖的一般指标[体重，体重指数（BMI），4个皮褶厚度之和，脂肪百分比，和体脂指数]和中心性肥胖（腰围、腰臀比、腰高比和基于皮褶厚度的躯干肥胖）。我们测量了血液样本中C反应蛋白、白细胞介素-6的浓度，以及胰岛素抵抗、甘油三酯、总胆固醇、低密度脂蛋白和高密度脂蛋白的稳态模型评估。我们使用相关和多元线性回归分析。肥胖症流行率（BMI-年龄z评分>2，世界卫生组织2006），向心性肥胖（>=第90百分位数，第三次全国健康与营养检查调查），血脂紊乱高（分别为13%、11%和>= 20%），70%的儿童至少有一种心脏代谢危险因素。肥胖和中心性肥胖指标之间的大多数相关性为中度至强（0.40 < r < 0.96）。肥胖与C-反应蛋白在男女中均呈正相关，但相关性较弱，与稳态模型评估的胰岛素抵抗仅在女孩中相关（所有r < 0.3，P < 0.05）。肥胖指标与白细胞介素6和血脂水平无关（P > 0.05）。总体而言，肥胖指标解释，最多，8%的变异cardiometabolic risk factors.Conclusions：肥胖和中心性肥胖是常见的，大多数儿童至少有一个心脏代谢危险因素，特别是血脂紊乱。肥胖和中心性肥胖指标高度相关，总体而言，与心脏代谢状态弱相关。在这个年龄段，体重指数和腰围是心脏代谢状态的不良预测因子。美国临床营养杂志2010; 91：166-74。
Background: In adults and adolescents, obesity is positively associated with cardiovascular disease risk factors; however, evidence in preschool children is scarce.Objective: The objective was to assess the relations between obesity indicators and cardiometabolic risk factors in 324 Chilean children 4 y of age.Design: We collected anthropometric measurements and calculated general indicators of obesity [weight, body mass index (BMI), sum of 4 skinfold thicknesses, percentage fat, and body fat index] and central obesity (waist circumference, waist-to-hip ratio, waist-to-height ratio, and truncal fatness based on skinfold thickness). We measured blood sample concentrations of C-reactive protein, interleukin-6, homeostasis model assessment of insulin resistance, triglycerides, and total, LDL, and HDL cholesterol. We used correlation and multiple linear regression analyses.Results: The prevalence of obesity (BMI-for-age z score >2, World Health Organization 2006), central obesity (>= 90th percentile, third National Health and Nutrition Examination Survey), and lipid disorders was high (13%, 11%, and >= 20%, respectively), and 70% of the children had at least one cardiometabolic risk factor. Most correlations between obesity and central obesity indicators were moderate to strong (0.40 < r < 0.96). Obesity was positively but weakly associated with C-reactive protein in both sexes and with homeostasis model assessment of insulin resistance only in girls (all r < 0.3, P < 0.05). Obesity indicators were unrelated to interleukin-6 and lipid concentrations (P > 0.05). Overall, obesity indicators explained, at most, 8% of the variability in cardiometabolic risk factors.Conclusions: Obesity and central obesity were common, and most of the children had at least one cardiometabolic risk factor, particularly lipid disorders. Obesity and central obesity indicators were highly intercorrelated and, overall, were weakly related to cardiometabolic status. At this age, body mass index and waist circumference were poor predictors of cardiometabolic status. Am J Clin Nutr 2010; 91: 166-74.