Silicon Nanofluidic Membrane for Electrostatic Control of Drugs and Analytes Elution
Silicon Nanofluidic Membrane for Electrostatic Control of Drugs and Analytes Elution
复制标题
DOI：
10.3390/pharmaceutics12070679
复制
发表时间：
2020-07-01
期刊：
影响因子：
5.4
通讯作者：
Grattoni, Alessandro
中科院分区：
文献类型：
--
作者：
Di Trani, Nicola;Silvestri, Antonia;Grattoni, Alessandro
尽管最近在药物制剂和植入装置方面取得了进展，但慢性病理的个体化长期管理仍然是一个难以实现的目标。缺乏可根据患者需求进行控制和定制的先进的治疗给药系统，妨碍了对诸如糖尿病、高血压、类风湿性关节炎等病症的最佳管理。已经证明了几种用于药物递送的触发系统。然而，它们大多依赖于连续的外部刺激，这阻碍了它们用于长期治疗。在这项工作中，我们研究了一种硅纳米流体技术，它结合了一个门电极，并检查其实现药物释放的可重复控制的能力。碳化硅（SiC）用于涂覆膜表面，包括纳米通道，确保生物相容性和化学惰性，以实现体内部署的长期稳定性。在小电压的作用下（
Individualized long-term management of chronic pathologies remains an elusive goal despite recent progress in drug formulation and implantable devices. The lack of advanced systems for therapeutic administration that can be controlled and tailored based on patient needs precludes optimal management of pathologies, such as diabetes, hypertension, rheumatoid arthritis. Several triggered systems for drug delivery have been demonstrated. However, they mostly rely on continuous external stimuli, which hinder their application for long-term treatments. In this work, we investigated a silicon nanofluidic technology that incorporates a gate electrode and examined its ability to achieve reproducible control of drug release. Silicon carbide (SiC) was used to coat the membrane surface, including nanochannels, ensuring biocompatibility and chemical inertness for long-term stability for in vivo deployment. With the application of a small voltage (