Differences of Retinal Blood Flow Between Arteries and Veins Determined by Laser Speckle Flowgraphy in Healthy Subjects.
Differences of Retinal Blood Flow Between Arteries and Veins Determined by Laser Speckle Flowgraphy in Healthy Subjects.
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DOI：
10.1097/md.0000000000001256
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发表时间：
2015-08
期刊：
影响因子：
1.6
通讯作者：
Terasaki H
中科院分区：
文献类型：
--
作者：
Iwase T;Ra E;Yamamoto K;Kaneko H;Ito Y;Terasaki H
表征通过激光散斑血流成像 (LSFG) 测定的健康受试者的总视网膜血流量。这项前瞻性横断面研究是在名古屋大学医院进行的。研究人员对 115 名健康受试者（平均年龄：39.4±16.1 岁）的 115 只右眼进行了研究。使用代表血流量的总视网膜流量指数（TRFI）分别测量视神经乳头周围视网膜动脉和静脉的总血流量。比较了 LSFG 和自适应光学 (AO) 相机测定的视网膜血管的管腔直径。将 LSFG 和 AO 相机获得的图像合并，并评估图像上代表红细胞速度的平均模糊率 (MBR) 的分布。静脉中的平均TRFI（1812±445，仲裁单位）显着高于动脉（1455±348，仲裁单位；P< 0.001）。线性回归分析显示动脉和静脉的TRFI之间存在显着相关性（P < 0.001）。线性回归分析还显示，LSFG 和 AO 相机测定的动脉和静脉直径之间存在高度显着相关性（动脉，r = 0.94，P < 0.001；静脉，r = 0.92，P < 0.001）。动脉中LSFG与AO相机测定的管腔直径之比（0.068 ± 0.005，仲裁单位）显着低于静脉（0.074 ± 0.007，仲裁单位）（P < 0.001）。静脉的 MBR 在整个管腔宽度内是均匀的；然而，动脉中的 MBR 在中心较高，靠近管腔壁较低。静脉中的 TRFI 高于动脉中的 TRFI，表明动脉中的视网膜血流量小于静脉中的视网膜血流量。然而，LSFG仍有可能存在固有的问题，即由于动脉的特性，LSFG确定的动脉管腔直径小于实际直径。这将导致 LSFG 中动脉中的视网膜血流量小于静脉中的血流量。
To characterize the total retinal blood flow determined by laser speckle flowgraphy (LSFG) of healthy subjects. This prospective cross-sectional study was conducted at the Nagoya University Hospital. One hundred fifteen right eyes of 115 healthy subjects (mean age: 39.4 ± 16.1 years) were studied. The total blood flow in the retinal arteries and veins around the optic nerve head was measured separately using the total retinal flow index (TRFI), which represents blood flow volume. The lumen diameters of the retinal vessels determined by LSFG and by adaptive optics (AO) camera were compared. The images obtained by LSFG and AO camera were merged, and the distribution of the mean blur rates (MBRs), which represent the velocities of the erythrocytes, was evaluated on the images. The mean TRFI in veins (1812 ± 445, arbitral units) was significantly higher than that in arteries (1455 ± 348, arbitral units; P < 0.001). Linear regression analysis showed a significant correlation between the TRFI in the arteries and veins (P < 0.001). Linear regression analysis also showed a highly significant correlation between the diameters of arteries and veins determined by LSFG and by the AO camera (arteries, r = 0.94, P < 0.001; veins, r = 0.92, P < 0.001). The ratios of the lumen diameters determined by LSFG to that by AO camera was significant lower in arteries (0.068 ± 0.005, arbitral units) than in veins (0.074 ± 0.007, arbitral units) (P < 0.001). The MBRs of veins were homogeneous throughout the width of the lumen; however, the MBRs in the arteries were higher at the center and lower close to the walls of the lumen. The higher TRFIs in the veins than in the arteries indicate that there is a smaller volume of retinal blood flow in arteries than veins. However, the possibility remains that LSFG has inherent problem that the arterial lumen diameter determined by LSFG is smaller than actual one because of the characteristics of arteries. This would result in a smaller volume of retinal blood flow in the arteries than veins in LSFG.