Diabetes, incidence in 0-to 14-year age-group in Italy - A 10-year prospective study
Diabetes, incidence in 0-to 14-year age-group in Italy - A 10-year prospective study
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DOI：
10.2337/diacare.27.12.2790
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发表时间：
2004-12-01
期刊：
影响因子：
16.2
通讯作者：
Cherubini, V
中科院分区：
文献类型：
--
作者：
Carle, F;Gesuita, R;Cherubini, V
目的 - 意大利 1 型糖尿病登记处 (RIDI) 研究小组的成立是为了协调意大利 1 型糖尿病的登记处。本报告基于 3,606 名 15 岁以下儿童，被诊断患有 1 型糖尿病，并在 1990 年至 1999 年期间由 9 个中心进行前瞻性登记，覆盖意大利人口的 35% 以上。 研究设计和方法 - 登记集中在四个地理宏观区域：北部、中部、南部和岛屿。登记的完整性通过捕获-重新捕获方法进行评估。泊松回归分析用于评估发病率的时间趋势。结果 - 不仅在撒丁岛和大陆之间而且在半岛地区之间也证实了发病率的巨大差异。在撒丁岛，男孩数量过多（男孩与女孩的发病率为 1.4）。意大利半岛和撒丁岛的总体发病率每年平均分别增加 3.6% (P < 0.001) 和 3.7% (P < 0.001)。 10-14 岁男孩（6.7%，95% CI 0.5-13.3）和 5-9 岁女孩的发病率显着增加。年（6.6%，0.5-13.1）居住在南部地区。生活在撒丁岛的 10-14 岁男孩（5.0%，0.3-1.0）和 0-4 岁女孩（4.9%，0.8-9.1）的发病率也有所增加。 结论 - 意大利是一个 1 型糖尿病发病率存在较大地理差异的国家。然而，在大陆和撒丁岛，这一比率正在均匀增加，这表明类似的环境因素在具有不同遗传背景的人群中发挥着作用。
OBJECTIVE - The Registry for Type 1 Diabetes Mellitus in Italy (RIDI) Study Group was established to coordinate the registries of type 1 diabetes in Italy. This report is based on 3,606 children younger than, 15 years diagnosed with type 1 diabetes and prospectively registered 1 during 1990-1999 by nine centers, covering >35% of the Italian population.RESEARCH DESIGN AND METHODS - Registries were pooled in four geographic macro-areas: north, central, South, and insular. The completeness of registration was assessed by the capture-recapture method. Poisson regression analysis was used to evaluate temporal trend in incidence.RESULTS - Large variations in incidence were confirmed not only between Sardegna and the mainland but also among peninsular areas. In Sardegna, there was an excess of boys (the boy-to-girl incidence ratio was 1.4). The overall incidence showed average increases of 3.6% (P < 0.001) and 3.7% (P < 0.001) per year in peninsular Italy and in Sardegna, respectively. Significant increases in incidence rates were found in boys aged 10-14 years (6.7%, 95% CI 0.5-13.3) and in girls aged 5-9. years (6.6%, 0.5-13.1) living in the southern area. The incidence rate also increased in boys aged 10-14 years (5.0%, 0.3-1.0) and in girls aged 0-4 years (4.9%, 0.8-9.1) living in Sardegna.CONCLUSIONS - Italy is a country with large geographical variations in incidence rates of type 1 diabetes. However, the rates are evenly increasing both in the mainland and Sardegna, suggesting that similar environmental factors are operating over populations that have different genetic backgrounds.