HISTOLOGY AND HISTOMORPHOMETRIC ANALYSIS OF THE NORMAL AND ATROPHIC HEEL FAT PAD
HISTOLOGY AND HISTOMORPHOMETRIC ANALYSIS OF THE NORMAL AND ATROPHIC HEEL FAT PAD
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DOI：
10.1177/107110079501600502
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发表时间：
1995-05-01
影响因子：
2.7
通讯作者：
RICCI, JL
中科院分区：
文献类型：
--
作者：
BUSCHMANN, WR;JAHSS, MH;RICCI, JL
光镜和电镜用于正常足跟脂肪垫和周围神经病变患者萎缩足跟脂肪垫的组织学检查。组织形态计量学分析显示，与正常足跟脂肪垫相比，萎缩脂肪垫的平均细胞面积平均小30%，平均细胞直径平均小16%。萎缩脂肪垫中的间隔壁通常破碎，比正常宽约75%。在萎缩的足跟脂肪垫中也发现了神经纤维化。Verhoeff弹性染色技术用于测定隔膜内胶原与弹性组织的相对百分比。正常足跟和萎缩足跟的脂肪细胞超微结构与腹部皮下脂肪相似。脂肪细胞中心的大小和密度可变的脂滴被细胞质的薄边缘包围。脂肪细胞之间的界面含有细小的胶原纤维和弹性纤维。
Light and electron microscopy was used for a histologic examination of normal heel fat pads and atrophic heel fat pads from patients with peripheral neuropathies. Histomorphometric analysis revealed an average 30% smaller mean cell area and 16% smaller mean cell diameters in the atrophic pads compared with the normal heel fat pads. Septal walls in the atrophic fat pads were often fragmented and approximately 75% wider than normal. Perineural fibrosis was also found in the atrophic heel fat pads. The Verhoeff elastic staining technique was used to determine the relative percentage of collagen to elastic tissue within the septae. No significant differences were noted between the normal and atrophic heels.The ultrastructure of the adipocytes from the normal and atrophic heel pads was similar to those found in abdominal subcutaneous fat. Lipid droplets of variable size and density within the center of the adipocyte were surrounded by a thin border of cytoplasm. The interphase between adipocytes contained fine collagen and elastic fibers.