Thalamic amplification of sensory input in experimental diabetes.
Thalamic amplification of sensory input in experimental diabetes.
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DOI：
10.1111/ejn.13267
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
Gardiner NJ
中科院分区：
文献类型：
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作者：
Freeman OJ;Evans MH;Cooper GJ;Petersen RS;Gardiner NJ
糖尿病性神经病变是糖尿病常见的继发性并发症，通常使人衰弱。由于疼痛、超敏反应和感觉异常存在于远端-近端分布中，因此通常认为症状源自外周神经系统内受损的传入神经。越来越多的证据表明，糖尿病神经病变中中枢神经系统内的处理改变有助于体感功能障碍，但糖尿病患者外周编码信息通过中枢神经系统的准确编码和传递是否改变尚不清楚。在这里，我们应用啮齿动物须桶系统的优势来研究糖尿病神经病变中的初级传入丘脑处理。我们发现，与非糖尿病大鼠相比，实验性糖尿病神经病变大鼠的丘脑腹后内侧核神经元显示出精确分级的多方向触须偏转放电增加。这种丘脑活动过度的发生没有任何明显的初级传入功能障碍，因为三叉神经节的记录显示这些初级传入不受糖尿病的影响。这些研究结果表明，中央放大可以大大改变上升的感觉输入糖尿病，即使在没有一个拦河坝异位初级传入活动。
Diabetic neuropathy is a common, and often debilitating, secondary complication of diabetes mellitus. As pain, hypersensitivity and paraesthesias present in a distal–proximal distribution, symptoms are generally believed to originate from damaged afferents within the peripheral nervous system. Increasing evidence suggests altered processing within the central nervous system in diabetic neuropathy contributes towards somatosensory dysfunction, but whether the accurate coding and relay of peripherally encoded information through the central nervous system is altered in diabetes is not understood. Here, we applied the strengths of the rodent whisker–barrel system to study primary afferent‐thalamic processing in diabetic neuropathy. We found that neurons in the thalamic ventral posteromedial nucleus from rats with experimental diabetic neuropathy showed increased firing to precisely graded, multidirectional whisker deflection compared to non‐diabetic rats. This thalamic hyperactivity occurred without any overt primary afferent dysfunction, as recordings from the trigeminal ganglion showed these primary afferents to be unaffected by diabetes. These findings suggest that central amplification can substantially transform ascending sensory input in diabetes, even in the absence of a barrage of ectopic primary afferent activity.