Sex Differences in Body Mass Index and Obesity in Chinese Patients With Chronic Schizophrenia
Sex Differences in Body Mass Index and Obesity in Chinese Patients With Chronic Schizophrenia
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DOI：
10.1097/jcp.0000000000000594
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发表时间：
2016-12-01
影响因子：
2.9
通讯作者：
Zhang, Xiang Yang
中科院分区：
文献类型：
--
作者：
Li, Qiongzhen;Chen, Dachuan;Zhang, Xiang Yang
精神分裂症的性别差异已经得到了很好的认识。然而，与抗精神病药物相关的肥胖的性别差异几乎没有得到系统的研究。本研究旨在比较抗精神病药物及相关危险因素对中国精神分裂症患者肥胖和体重指数(BMI)的性别差异影响。纳入慢性精神分裂症住院患者204例(男/女=140/66)。收集人口学和临床数据，并测量血糖和血脂水平。采用阳性与阴性症状量表(PANSS)评定患者的精神病理状态。女性患者的肥胖率(21/66，31.82%)约为男性患者(22/140，15.83%；P<；0.001)的2倍；女性的体重指数也高于男性(25.49±4.42 kg/m(2)vs23.95±3.67 kg/m(2)；P<；0.005)。回归分析显示，在女性中，肥胖与2型糖尿病(P<；0.05)和甘油三酯(P<；0.05)有关，而在男性(P<；0.01)，肥胖与甘油三酯有关。进一步相关分析显示，男性BMI与PANSS阴性症状分(P<；0.001)和PANSS总分(P<；0.01)相关。此外，女性的低密度脂蛋白水平高于男性。本研究结果提示，长期服药的精神分裂症患者在体重和肥胖方面存在明显的性别差异，女性患者的脂代谢紊乱程度更严重。
Sex differences in schizophrenia have been well recognized. However, sex differences in obesity associated with antipsychotics have received little systematic study. This studywas conducted to compare sex difference effects of antipsychotics and related risk factors on obesity and body mass index (BMI) in Chinese patients with schizophrenia. A total of 204 inpatients with chronic schizophrenia (males/females = 140/66) were recruited. Demographic and clinical data were collected, and serum glucose and lipid levels were measured. The Positive and Negative Syndrome Scale (PANSS) was used to assess patients' psychopathology. The prevalence of obesity in female patients (21/66, 31.82%) was approximately 2 times that of male patients (22/140, 15.83%; P < 0.001) and women also had higher BMI than men (25.49 +/- 4.42 kg/m(2) versus 23.95 +/- 3.67 kg/m(2); P < 0.005). Regression analyses showed that obesity was associated with type 2 diabetes (P < 0.05) and triglycerides (P < 0.05) in women, and limited to triglyceride in men (P < 0.01). Further correlation analysis showed that BMI was associated with the PANSS negative symptom subscore (P < 0.001) and the PANSS total score (P < 0.01) in men. In addition, women had higher low-density lipoprotein plasma levels than men. Our findings suggest that there are significant sex differences in bodyweight and obesity in chronic medicated patients with schizophrenia, with worse lipid metabolic dysfunction in female patients.