VITAMIN-E PREVENTS ENDOTHELIAL INJURY ASSOCIATED WITH CISPLATIN INJECTION INTO THE SUPERIOR MESENTERIC-ARTERY OF RATS
VITAMIN-E PREVENTS ENDOTHELIAL INJURY ASSOCIATED WITH CISPLATIN INJECTION INTO THE SUPERIOR MESENTERIC-ARTERY OF RATS
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DOI：
10.1007/bf01744983
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发表时间：
1995-01-01
影响因子：
1.5
通讯作者：
SUZUKI, T
中科院分区：
文献类型：
--
作者：
ITO, H;OKAFUJI, T;SUZUKI, T
为了阐明抗肿瘤药物引起的血管损伤的发病机制，将顺铂与碘油一起注入大鼠肠系膜上动脉。给药4天后检查血管壁的形态和生化变化以及维生素E的预防作用。在顺铂治疗组中，但在其他组中没有观察到严重的内皮损伤，例如空泡形成、内皮下水肿和内弹性膜破坏。超氧化物歧化酶（一种有效的超氧阴离子清除剂）在顺铂组中显着较低，并且Na/K-ATP酶（质膜标记物）在该组中也较低。这些形态学变化很小，维生素 E 治疗组的酶活性高于顺铂治疗组。这些结果表明，顺铂给药后的内皮损伤可能是由自由基诱导的膜系统脂质过氧化引起的，并且联合给予维生素E可以预防这种损伤。
To clarify the pathogenesis of the vascular injury caused by the administration of anti-neoplastic drugs, cisplatin with lipiodol was infused into the superior mesenteric artery of rats. Morphological and biochemical changes in the vascular wall and the prophylactic effects of vitamin E were examined 4 days after administration. In the cisplatin-treated group, but not in the other groups, severe endothelial injury, such as vacuolation, subendothelial edema, and destruction of the internal elastic membrane, was observed. Superoxide dismutase, a potent scavenger of the superoxide anion, was markedly lower in the cisplatin group, and Na/K-ATPase, a marker of the plasma membrane, was also low in this group. These morphological changes were minimal, and enzyme activity was higher in the vitamin E-treated group than in the cisplatin-treated group. These findings indicate that endothelial injury after cisplatin administration could be caused by free radical-induced lipid peroxidation of the membrane system, and that such injury may be prevented by the co-administration of vitamin E.