Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
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DOI：
10.1038/ni1380
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发表时间：
2006-09-01
影响因子：
30.5
通讯作者：
Kronenberg, Mitchell
中科院分区：
文献类型：
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作者：
Kinjo, Yuki;Tupin, Emmanuel;Kronenberg, Mitchell
自然杀伤T(NKT)细胞识别CD1d分子提出的糖鞘糖脂，并与防御微生物感染有关。以前定义的由NKT细胞识别的外源糖鞘糖脂是在非致病性鞘氨醇单胞菌中唯一发现的。在这里，我们展示了小鼠和人类NKT细胞也识别来自伯氏疏螺旋体的糖脂，特别是二酰甘油，它会导致莱姆病。伯氏杆菌来源的糖脂诱导NKT细胞增殖和细胞因子的产生，这种糖脂的抗原性依赖于酰链长度和饱和度。这些数据表明，NKT细胞识别的糖脂种类超过了鞘氨醇单胞菌中的糖脂种类，并提示由T细胞受体介导的糖脂识别驱动的NKT细胞反应可能对不同的病原体提供保护。
Natural killer T ( NKT) cells recognize glycosphingolipids presented by CD1d molecules and have been linked to defense against microbial infections. Previously defined foreign glycosphingolipids recognized by NKT cells are uniquely found in nonpathogenic sphingomonas bacteria. Here we show that mouse and human NKT cells also recognized glycolipids, specifically a diacylglycerol, from Borrelia burgdorferi, which causes Lyme disease. The B. burgdorferi-derived, glycolipid- induced NKT cell proliferation and cytokine production and the antigenic potency of this glycolipid was dependent on acyl chain length and saturation. These data indicate that NKT cells recognize categories of glycolipids beyond those in sphingomonas and suggest that NKT cell responses driven by T cell receptor-mediated glycolipid recognition may provide protection against diverse pathogens.