Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?
Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?
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DOI：
10.3390/ijms160817565
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发表时间：
2015-07-31
影响因子：
5.6
通讯作者：
Tumani H
中科院分区：
文献类型：
--
作者：
Abdelhak A;Junker A;Brettschneider J;Kassubek J;Ludolph AC;Otto M;Tumani H
许多神经退行性疾病共享一个共同的病理生理学途径，涉及轴突变性，尽管不同的病因触发。分析脑脊液（CSF）中的神经丝、tau蛋白和微管蛋白等细胞骨架标记物可能是检测疾病过程中轴突损伤过程及其严重程度的有用方法。在这篇文章中，我们回顾了已发表的文献中关于脑特异性CSF标记物的细胞骨架损伤在原发性进行性多发性硬化症和肌萎缩侧索硬化症，以评估其效用作为一种生物标志物的疾病进展结合成像和组织学标记物，也可能是有用的其他神经退行性疾病与影响的上运动神经元。这种方法的长期益处可能是促进早期诊断和预后工具以及评估疾病修饰药物的治疗效果。
Many neurodegenerative disorders share a common pathophysiological pathway involving axonal degeneration despite different etiological triggers. Analysis of cytoskeletal markers such as neurofilaments, protein tau and tubulin in cerebrospinal fluid (CSF) may be a useful approach to detect the process of axonal damage and its severity during disease course. In this article, we review the published literature regarding brain-specific CSF markers for cytoskeletal damage in primary progressive multiple sclerosis and amyotrophic lateral sclerosis in order to evaluate their utility as a biomarker for disease progression in conjunction with imaging and histological markers which might also be useful in other neurodegenerative diseases associated with affection of the upper motor neurons. A long-term benefit of such an approach could be facilitating early diagnostic and prognostic tools and assessment of treatment efficacy of disease modifying drugs.