Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.
Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.
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DOI：
10.1152/physrev.00009.2012
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发表时间：
2012-10
影响因子：
33.6
通讯作者：
Delpire E
中科院分区：
文献类型：
--
作者：
Gagnon KB;Delpire E
SPAK（Ste 20相关脯氨酸丙氨酸富集激酶）和OSR 1（氧化应激应答激酶）是哺乳动物Ste 20（Sterile 20）相关蛋白激酶家族的生发中心激酶VI亚家族的成员。虽然在这个蛋白激酶家族中有30种酶，但它们在真菌、植物和动物王国中的保守性证实了它们在进化上的重要性。已经有大量的工作积累了组织分布，结合伙伴，信号级联，和哺乳动物SPAK和OSR 1在多器官系统中的生理作用。在回顾这些基本信息后，我们将研究新的研究，证明SPAK和/或OSR 1中断的病理生理后果，讨论基因工程小鼠模型的开发和分析，并解决这些丝氨酸/苏氨酸激酶可能在癌症增殖和迁移中的作用。
SPAK (Ste20-related proline alanine rich kinase) and OSR1 (oxidative stress responsive kinase) are members of the germinal center kinase VI sub-family of the mammalian Ste20 (Sterile20)-related protein kinase family. Although there are 30 enzymes in this protein kinase family, their conservation across the fungi, plant and animal kingdom confirms their evolutionary importance. Already, a large volume of work has accumulated on the tissue distribution, binding partners, signaling cascades, and physiological roles of mammalian SPAK and OSR1 in multiple organ systems. After reviewing this basic information, we will examine newer studies that demonstrate the pathophysiological consequences to SPAK and/or OSR1 disruption, discuss the development and analysis of genetically-engineered mouse models, and address the possible role these serine/threonine kinases might have in cancer proliferation and migration.