[Analysis of the factors associated with abnormal coagulation and prognosis in patients with non-small cell lung cancer].
[Analysis of the factors associated with abnormal coagulation and prognosis
in patients with non-small cell lung cancer].
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DOI：
10.3779/j.issn.1009-3419.2014.11.04
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发表时间：
2014-11-01
期刊：
影响因子：
--
通讯作者：
Wang, Cai
中科院分区：
文献类型：
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作者：
Li, Yanhua;Wei, Suju;Wang, Cai
背景与目的：凝血和纤溶的激活是癌症患者经常遇到的问题。这类肿瘤具有较高的侵袭、转移和阴性结局的风险。非小细胞肺癌（NSCLC）约占所有肺部恶性肿瘤的80%至85%。本研究旨在探讨凝血试验对非小细胞肺癌的预后价值，为患者预防和治疗血栓形成提供参考。方法：收集2009年1月至2012年12月河北医科大学第四医院604例经组织学证实的非小细胞肺癌住院患者的资料。数据包括治疗前患者凝血功能相关指标[即凝血酶原时间（PT）、凝血酶原时间活性（PTA）、国际标准化比值（INR）、活化部分凝血活酶时间（APTT）、纤维蛋白原（Fib）、d -二聚体、血小板计数]，以及性别、年龄、病理类型、TNM分期、淋巴结状况。50名未患癌症的对照组被纳入分析。采用SPSS 13.0软件进行统计分析。结果：患者血浆各项凝血指标d -二聚体、Fib、PT、APTT、INR、血小板计数与对照组比较差异均有统计学意义(P
BACKGROUND AND OBJECTIVE: The activation of coagulation and fibrinolysis is frequently encountered among cancer patients. Such tumors are associated with high risk of invasion, metastases, and negative final outcomes. Non-small cell lung cancer (NSCLC) accounts for approximately 80% to 85% of all lung malignancies. This study aims to investigate the prognostic value of blood coagulation tests for NSCLC and provide a reference to patients on the prevention and treatment of thrombophilia.METHODS: Data were collected from 604 cases of hospitalized patients with histologically confirmed NSCLC from January 2009 to December 2012 at the Fourth Hospital of Hebei Medical University. Data included the related indexes of coagulation function in patients before treatment [(i.e., prothrombin time (PT), prothrombin time activity (PTA), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (Fib), D-dimer, and platelet count)], as well as sex, age, pathological type, TNM stage, and lymph node status. Fifty control subjects without cancer were included in the analysis. Statistical analysis was conducted by using SPSS 13.0 software.RESULTS: The plasma level of all coagulation tests including D-dimer, Fib, PT, APTT, INR, and platelet counts revealed statistically significant differences between the patient and control group (P