Metal-Phenolic Surfaces for Generating Therapeutic Nitric Oxide Gas
Metal-Phenolic Surfaces for Generating Therapeutic Nitric Oxide Gas
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用于产生治疗性一氧化氮气体的金属酚醛表面
DOI：
10.1021/acs.chemmater.8b01876
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发表时间：
2018-08-14
影响因子：
8.6
通讯作者：
Huang, Nan
中科院分区：
文献类型：
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作者：
Yang, Zhilu;Yang, Ying;Huang, Nan
聚多巴胺和其他酚类网络的材料独立表面化学在生物医学、能量存储和环境科学的几乎所有科学和工程领域都具有重大影响。在几乎所有类型的材料表面上，可以根据需要进行功能分子的固定、润湿性控制、导电涂层、细胞培养、聚合物生长等。然而，使用现有的材料独立的表面化学建立催化性能的策略仍然是一个广泛的研究领域。在此，我们开发了一种在铜-酚-胺网络中提供谷胱甘肽过氧化物酶（GPx）样活性的方法。界面催化活性导致从表面催化产生一氧化氮（NO），其能力为1至14 × 10-10 mol cm-2 min-1。优化的涂层不仅显著抑制血小板活化和平滑肌细胞（SMC）增殖，而且选择性地支持内皮细胞（EC）生长。这个...
Material-independent surface chemistry by polydopamine and other phenolic networks is of great influence in nearly all science and engineering fields in biomedical, energy storage, and environmental sciences. On nearly all types of material surface, immobilizations of functional molecules, wettability controls, conductive coatings, cell cultures, polymer growth, and others can be conducted on demand. However, strategies for establishing catalytic properties using the existing material-independent surface chemistry remain an extensive research area. Herein, we developed a method to providing glutathione peroxidase (GPx)-like activity in the network of copper-phenolic-amine. The interfacial catalytic activity results in a catalytic generation of nitric oxide (NO) from surfaces with a capability of 1 to 14 × 10–10 mol cm–2 min–1. The optimized coatings not only significantly inhibit platelet activation and smooth muscle cell (SMC) proliferation, but also selectively support endothelial cell (EC) growth. This...