Anticancer Potency Studies of Coordination Driven SelfAssembledArene- Ru- Based Metalla- Bowls
Anticancer Potency Studies of Coordination Driven SelfAssembledArene- Ru- Based Metalla- Bowls
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DOI：
10.1002/cbic.201300688
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发表时间：
2014-03-21
期刊：
影响因子：
3.2
通讯作者：
Chi, Ki-Whan
中科院分区：
文献类型：
--
作者：
Mishra, Anurag;Jeong, Yong Joon;Chi, Ki-Whan
具有通式[Ru-4]的新的四核阳离子金属碗5-7（对异丙基甲苯）（4）（NN）（2）（OOOO）（2）]（4+）（NN= 2，6-双（N-（4-吡啶基氨基甲酰基）吡啶，OOOO= 2，5-二羟基-1，4-苯醌基（5），OOOO= 5，8-二氧基-1，4-萘醌基（6），在AgO_3SCF_3存在下，通过双核钌配合物2-4与双吡啶酰胺给体配体1在甲醇中反应，合成了一系列新的金属配合物（7）。通过包括元素分析以及H-1和C-13 NMR和HR-ESI-MS光谱的分析技术充分表征碗。金属碗6的结构由X射线晶体衍射数据确定。紫外/可见光的研究也进行了整个套件的新的配合物。与最近对类似芳烃-Ru络合物的研究一样，针对SK-hep-1（肝癌）、AGS（胃癌）和HCT-15（结肠直肠癌）人癌细胞系建立了金属碗对细胞生长的抑制。发现6对所有癌细胞系的细胞生长抑制作用比抗癌药物阿霉素和顺铂强得多。特别是，在结直肠癌细胞中，暴露于6.
New tetranuclear cationic metalla-bowls 5-7 with the general formula [Ru-4(p-cymene)(4)(NN)(2)(OOOO)(2)](4+) (NN=2,6-bis(N-(4-pyridyl carbamoyl)pyridine, OOOO=2,5-dihydroxy-1,4-benzoquinonato (5), OOOO=5,8-dioxydo-1,4-naphthaquinonato (6), OOOO=hoxonato (7)) were prepared by the reaction of the respective dinuclear ruthenium complexes 2-4 with a bispyridine amide donor ligand 1 in methanol in the presence of AgO3SCF3.These new molecular metalla-bowls were fully characterized by analytical techniques including elemental analysis as well as H-1 and C-13 NMR and HR-ESI-MS spectroscopy. The structure of metalla-bowl 6 was determined from X-ray crystal diffraction data. A UV/visible study was also carried out for the entire suite of new complexes. As with recent studies of similar arene-Ru complexes, the inhibition of cell growth by metalla-bowls was established against SK-hep-1 (liver cancer), AGS (gastric cancer), and HCT-15 (colorectal cancer) human cancer cell lines. Inhibition of cell growth by 6 was found to be considerably stronger against all cancer cell lines than the anticancer drugs, doxorubicin and cisplatin. In particular, in colorectal cancer cells, expression of the cancer suppressor genes APC and p53 was increased following exposure to 6.