Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
复制标题
DOI：
10.1016/j.toxlet.2012.08.029
复制
发表时间：
2012-11-15
影响因子：
3.5
通讯作者：
Aramaki, Hironori
中科院分区：
文献类型：
--
作者：
Takeda, Shuso;Okajima, Shunsuke;Miyoshi, Hiroko;Yoshida, Kazutaka;Okamoto, Yoshiko;Okada, Tomoko;Amamoto, Toshiaki;Watanabe, Kazuhito;Omiecinski, Curtis J.;Aramaki, Hironori
大麻二酚（CBD）是纤维型大麻植物的主要非精神药物成分，具有多种生物活性，包括抗肿瘤细胞增殖作用。虽然CBD是从其母体分子大麻二酚酸（CBDA）的非酶促脱羧反应中获得的，但很少有研究调查CBDA本身是否具有生物活性。目前的研究结果表明，CBDA抑制高度侵袭性MDA-MB-231人乳腺癌细胞的迁移，显然是通过抑制cAMP依赖性蛋白激酶A以及激活小GTdR，RhoA的机制。已确定RhoA信号传导途径的激活导致抑制各种癌细胞（包括MDA-MB-231细胞）的移动性。本报告中提供的数据首次表明，作为大麻植物中的活性成分，CBDA在消除癌细胞迁移（包括侵袭性乳腺癌）方面提供了潜在的治疗方式。
Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, including anti-proliferative effect on cancer cells. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), few studies have investigated whether CBDA itself is biologically active. Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. It is established that activation of the RhoA signaling pathway leads to inhibition of the mobility of various cancer cells, including MDA-MB-231 cells. The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.
登录
查看更多内容
影响因子：
4.1
作者：
Takeda S;Matsuo K;Yaji K;Okajima-Miyazaki S;Harada M;Miyoshi H;Okamoto Y;Amamoto T;Shindo M;Omiecinski CJ;Aramaki H
通讯作者：
Aramaki H
影响因子：
8.5
作者：
Banu, N.;Buda, A.;Pignatelli, M.
通讯作者：
Pignatelli, M.
影响因子：
5.7
作者：
McAllister, Sean D.;Christian, Rigel T.;Desprez, Pierre-Yves
通讯作者：
Desprez, Pierre-Yves
影响因子：
4
作者：
Ohta, Hironori;Hamada, Jun-ichi;Moriuchi, Tetsuya
通讯作者：
Moriuchi, Tetsuya
影响因子：
11.2
作者：
Simpson, KJ;Dugan, AS;Mercurio, AM
通讯作者：
Mercurio, AM