The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation.
The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation.
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DOI：
10.1053/j.gastro.2016.10.046
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发表时间：
2017-03
期刊：
影响因子：
29.4
通讯作者：
Boeckxstaens GE
中科院分区：
文献类型：
--
作者：
Browning KN;Verheijden S;Boeckxstaens GE
虽然胃肠道（GI）包含内在神经丛，允许对GI功能进行显著程度的独立控制，但中枢神经系统提供调节、调节和整合这些功能的外在神经输入。特别是迷走神经（VN）为胃肠道提供副交感神经支配，协调中枢和外周神经控制机制之间的复杂相互作用。本文将讨论传入（感觉）和运动（传出）迷走神经在调节食欲，情绪和免疫系统的生理作用，以及VN功能障碍导致肥胖，情绪障碍和炎症的病理生理结果。VN调制的治疗潜力，以减轻或扭转这些病理生理结果和恢复自主稳态也将进行讨论。
Although the gastrointestinal (GI) tract contains intrinsic neural plexuses that allow a significant degree of independent control over GI functions, the central nervous system provides extrinsic neural inputs that modulate, regulate and integrate these functions. In particular, the vagus nerve (VN) provides the parasympathetic innervation to the GI tract, co-ordinates the complex interactions between central and peripheral neural control mechanisms. This review will discuss the physiological roles of the afferent (sensory) and motor (efferent) vagus in regulation of appetite, mood and the immune system, as well as the pathophysiological outcomes of VN dysfunction resulting in obesity, mood disorders and inflammation. The therapeutic potential of VN modulation to attenuate or reverse these pathophysiological outcomes and restore autonomic homeostasis will also be discussed.