An actigraphy study investigating sleep in bipolar I patients, unaffected siblings and controls.
An actigraphy study investigating sleep in bipolar I patients, unaffected siblings and controls.
复制标题
一项体动记录研究调查了 I 型双相情感障碍患者、未受影响的兄弟姐妹和对照组的睡眠情况。
DOI：
10.1016/j.jad.2016.08.076
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发表时间：
2017
影响因子：
6.6
通讯作者：
Ophoff,RoelA
中科院分区：
文献类型：
--
作者：
Verkooijen,Sanne;vanBergen,AnnetH;Knapen,StefanE;Vreeker,Annabel;Abramovic,Lucija;Pagani,Lucia;Jung,Yoon;Riemersma-vanderLek,Rixt;Schoevers,RobertA;Takahashi,JosephS;Kahn,RenéS;Boks,MarcoPM;Ophoff,RoelA
目的双相情感障碍患者在情绪发作时，睡眠和清醒模式的紊乱非常普遍。问题仍然是这些干扰是否持续在正常心境阶段，以及它们是否是双相情感障碍的遗传特征。目前的研究调查客观的睡眠措施在一个大样本的双相I型患者，非受影响的兄弟姐妹和controls.MethodsA共107双相I型患者，74个非受影响的兄弟姐妹，和80个控制被包括在内。在14天的时间里，用活动记录仪测量睡眠。七个睡眠参数进行了分析组的差异和他们之间的关系，发病年龄，发作次数和精神病症状，使用线性混合模型分析，占家庭dependency.ResultsPatients有较长的睡眠时间和较晚的时间睡眠偏移相比，非受影响的兄弟姐妹，但这些差异完全归因于情绪症状的差异。当分析仅限于正常胸腺患者时，我们发现患者与对照组或同胞与对照组之间无差异。没有双相情感障碍的特征与sleep.LimitationsMedication的使用没有考虑到这可能会影响我们的研究结果和控制是年轻相比，nonaffected siblings.ConclusionsIn the largest study to date，我们的研究结果表明，恢复双相I型患者和他们的兄弟姐妹不经历临床显着的睡眠障碍。睡眠障碍主要是当前情绪状态的反映，但与疾病的过程无关。
ObjectivesDisturbances in sleep and waking patterns are highly prevalent during mood episodes in bipolar disorder. The question remains whether these disturbances persist during phases of euthymia and whether they are heritable traits of bipolar disorder. The current study investigates objective sleep measures in a large sample of bipolar I patients, non-affected siblings and controls.MethodsA total of 107 bipolar disorder I patients, 74 non-affected siblings, and 80 controls were included. Sleep was measured with actigraphy over the course of 14 days. Seven sleep parameters were analyzed for group differences and their relationship with age at onset, number of episodes and psychotic symptoms using linear mixed model analysis to account for family dependencies.ResultsPatients had a longer sleep duration and later time of sleep offset compared to the non-affected siblings but these differences were entirely attributable to differences in mood symptoms. We found no difference between patients and controls or siblings and controls when the analyses were restricted to euthymic patients. None of the bipolar illness characteristics were associated with sleep.LimitationsMedication use was not taken into account which may have influenced our findings and controls were younger compared to non-affected siblings.ConclusionsIn the largest study to date, our findings suggest that recovered bipolar I patients and their siblings do not experience clinically significant sleep disturbances. Sleep disturbances are primarily a reflection of current mood state, but are unrelated to the course of the disorder.