The relationship between dental status and health-related quality of life in upper aerodigestive tract cancer patients.
The relationship between dental status and health-related quality of life in upper aerodigestive tract cancer patients.
复制标题
上呼吸消化道癌症患者牙齿状况与健康相关生活质量之间的关系。
DOI：
10.1016/s1368-8375(98)00108-0
复制
发表时间：
1999
期刊：
影响因子：
4.8
通讯作者：
J. S. Feine
中科院分区：
文献类型：
--
作者：
Paul J. Allison;David Locker;J. S. Feine
虽然上呼吸消化道（UADT）癌症治疗的口腔后遗症已经得到了很好的描述，但对UADT癌症患者的牙齿状况和健康相关生活质量（HRQL）之间的关系知之甚少。本研究的目的是调查的假设，牙齿状态是一个预测HRQL的样本治疗后UADT癌症患者。采用横断面研究设计，样本为188名受试者。通过EORTC QLQ-C30工具的全局域评估HRQL，并收集有关社会人口统计学、疾病、治疗和牙齿状态变量的数据。线性多元回归分析用于确定与HRQL有显著独立关联的变量。两个多变量模型分别包含年龄，性别，就业状况，癌症部位和疾病阶段，加上牙齿状态类别“部分牙齿无修复体”（P/NP）（模型的F值=7.31; P<0.0001; r2=0.20），其预测HRQL显著更差，或牙齿状态类别“有修复体的缺牙”（E/WP）（模型的F值=7.56; P<0.0001; r2=0.20），预测HRQL显著更好。此外，P/NP组报告的“牙齿问题”（ANOVA，P=0.0004）、“进食困难”（ANOVA，P=0.024）和“用餐困难”（ANOVA，P=0.01）显著更多。尽管数据收集的横截面性质和牙齿状态变量的某种粗糙性质限制了推断，但本研究的结果表明，牙齿状态对治疗后UADT癌症患者的HRQL具有重要影响。
Although the oral sequelae of treatments for upper aerodigestive tract (UADT) cancers have been well described, very little is known about the relationship between dental status and health-related quality of life (HRQL) in patients with UADT cancer. The aim of this study was to investigate the hypothesis that dental status is a predictor of HRQL in a sample of post-therapeutic UADT cancer patients. A cross-sectional study design was used with a sample of 188 subjects. HRQL was evaluated through the global domain of the EORTC QLQ-C30 instrument and data were collected on sociodemographic, disease, treatment and dental status variables. Linear multiple regression analysis was used to determine those variables with a significant independent association with the HRQL. Two multivariate models were developed each containing age, gender, employment status, cancer site and disease stage, plus either the dental status category “partially dentate with no prosthesis” (P/NP) (F-value for model=7.31; P<0.0001; r2=0.20) which predicted a significantly worse HRQL, or the dental status category “edentulous with prostheses” (E/WP) (F-value for model=7.56; P<0.0001; r2=0.20) which predicted a significantly better HRQL. Furthermore, the P/NP group reported significantly more “problems with their teeth” (ANOVA, P=0.0004), significantly more “trouble eating” (ANOVA, P=0.024) and significantly more “trouble enjoying their meals” (ANOVA, P=0.01). Although the cross-sectional nature of the data collection and the somewhat crude nature of the dental status variable limit inferences, the results of this study suggest that dental status has an important effect on HRQL in post-therapeutic UADT cancer patients.