Redox-Neutral Iron-Sulfur Promoted Transformation of 2-Nitrophenols and 2,6-Disubstituted p-Cresols into 2-Arylbenzoxazoles
Redox-Neutral Iron-Sulfur Promoted Transformation of 2-Nitrophenols and 2,6-Disubstituted p-Cresols into 2-Arylbenzoxazoles
复制标题
氧化还原中性铁硫促进 2-硝基酚和 2,6-二取代对甲酚转化为 2-芳基苯并恶唑
DOI：
10.1055/s-0033-1338995
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发表时间：
2014
期刊：
影响因子：
2
通讯作者：
Takumi Mizuno
中科院分区：
文献类型：
--
作者：
Masahiko Saibara;Kazuhito Ashida;Kouji Satomi;Toshiyuki Iwai;Takeo Nakai;Masatoshi Mihara;Takatoshi Ito;Takumi Mizuno
一种基于铁和单质硫的催化剂已被证明可以有效地促进2-硝基苯酚和2,6-二取代对甲酚之间的氧化还原-中性反应，从而以较高的收率制备2-芳基苯并恶唑。这种合成方法还提供了高原子经济性，而不使用任何外部氧化和/或还原试剂。这是第一个2-硝基苯酚与2,6-二取代甲酚的氧化还原缩合反应。
A catalyst based on iron and elemental sulfur has been shown to efficiently promote a redox-neutral reaction between 2-nitrophenols and 2,6-disubstitutedp-cresols, allowing for the preparation of 2-arylbenzoxazoles in good yields. This synthetic methodology also affords high atom economy without the use of any external oxidizing and/or reducing reagents. This is the first redox–condensation reaction of 2-nitrophenols with 2,6-disubstitutedp-cresols.