Coexistence and specialization of pathogen strains on contact networks
Coexistence and specialization of pathogen strains on contact networks
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DOI：
10.1086/505760
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发表时间：
2006-08-01
影响因子：
2.9
通讯作者：
Keeling, Matt J.
中科院分区：
文献类型：
--
作者：
Eames, Ken T. D.;Keeling, Matt J.
不同病原体菌株的共存对病原体变异性和疾病控制具有影响，并且已经以许多不同的方式进行了解释。我们使用接触网络，它代表了感染可能传播的个体之间的相互作用，以调查菌株共存。对于性传播疾病，接触网络的结构得到了详细的研究，并已被证明是流行病学动态的一个重要决定因素。通过使用分析成对模型和随机模拟，我们证明了网络结构也对病原体菌株之间的相互作用有着深远的影响。特别是，当人口是连续一夫一妻制，完全交叉反应菌株可以共存，不同的菌株在网络区域占主导地位，具有不同的特点。此外，我们观察到网络内不同风险组中不同菌株的专业化，表明存在不同的进化压力。
The coexistence of different pathogen strains has implications for pathogen variability and disease control and has been explained in a number of different ways. We use contact networks, which represent interactions between individuals through which infection could be transmitted, to investigate strain coexistence. For sexually transmitted diseases the structure of contact networks has received detailed study and has been shown to be a vital determinant of the epidemiological dynamics. By using analytical pairwise models and stochastic simulations, we demonstrate that network structure also has a profound influence on the interaction between pathogen strains. In particular, when the population is serially monogamous, fully cross-reactive strains can coexist, with different strains dominating in network regions with different characteristics. Furthermore, we observe specialization of different strains in different risk groups within the network, suggesting the existence of diverging evolutionary pressures.