Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites
Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites
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DOI：
10.1002/dvdy.1211
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发表时间：
2001-11
影响因子：
2.5
通讯作者：
F. Schubert;P. Tremblay;A. Mansouri;A. M. Faisst;B. Kammandel;A. Lumsden;P. Gruss;S. Dietrich
中科院分区：
文献类型：
--
作者：
F. Schubert;P. Tremblay;A. Mansouri;A. M. Faisst;B. Kammandel;A. Lumsden;P. Gruss;S. Dietrich
包含转录因子Pax3的配对框是皮肤组织和肌肉发育的关键调节因子。然而，Pax3/ spot突变的等位基因系列也表现出特征性的脊柱畸形，这不是由背腹体模式缺陷引起的。更确切地说，脊柱和硬核表型与分割/体细胞发生突变体rachiterata和puggy中观察到的表型相似。此外，通过Uncx4.1和Lunatic fringe的表达监测，斑点中体位模式和体位边界受到干扰。EphA4、Dll1和Uncx4.1的表达在凝聚的近轴中胚层中已经明显改变，这与体形成前和体形成过程中Pax3的第一阶段表达有关。这一发现提示Pax3在上皮体形成过程中的早期功能。©2001 Wiley‐Liss, Inc。
The paired box containing transcription factor Pax3 is a crucial regulator of dermomyotome and muscle development. However, the allelic series of Pax3/Splotch mutants also displays characteristic vertebral column malformations, which do not result from defective dorsoventral somite pattern. Rather, vertebral column and sclerotomal phenotypes are reminiscent of the phenotypes observed in the segmentation/somitogenesis mutants rachiterata and pudgy. Moreover, rostrocaudal somite pattern and somitic boundaries are disturbed in Splotch as monitored by the expression of Uncx4.1 and Lunatic fringe. Alterations in EphA4, Dll1, and Uncx4.1 expression are evident already in the condensing paraxial mesoderm, correlating with the first phase of Pax3 expression before and during somite formation. This finding suggests an early function of Pax3 during the formation of epithelial somites. © 2001 Wiley‐Liss, Inc.