CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells
CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells
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DOI：
10.1111/j.1440-1827.2007.02097.x
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发表时间：
2007-05-01
影响因子：
2.2
通讯作者：
Takahashi, Masahide
中科院分区：
文献类型：
--
作者：
Hasegawa, Masaki;Hagiwara, Sumitaka;Takahashi, Masahide
CD109基因编码糖基磷脂酰肌醇（GPI）锚定的细胞表面蛋白。本文显示，CD109在乳腺、唾液腺和泪腺的肌上皮细胞中以及在前列腺基底细胞中高度表达。作者制备的抗CD109抗体可用于福尔马林固定的石蜡切片，它强烈染色肌上皮细胞和基底细胞，但不染色这些腺体中的导管、腺泡和分泌细胞。CD109在乳腺导管癌和前列腺癌中表达阴性。这些发现表明，CD109是一个有用的标记物，用于诊断浸润性乳腺癌和前列腺癌。
The CD109 gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface protein. Herein it is shown that CD109 is highly expressed in myoepithelial cells of mammary, salivary, and lacrimal glands; and in prostate basal cells. The anti-CD109 antibody generated by the authors was available for formalin-fixed paraffin section, and it strongly stained myoepithelial cells and basal cells but not ductal, acinar, and secretory cells in these glands. CD109 expression was negative in examined breast ductal carcinomas and prostate adenocarcinomas. These findings indicate that CD109 is a useful marker for the diagnosis of invasive breast and prostate carcinomas.