Algorithms for selected blood acid-base and blood gas calculations.
Algorithms for selected blood acid-base and blood gas calculations.
复制标题
用于选定血液酸碱和血气计算的算法。
DOI：
10.1152/jappl.1972.33.1.154
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发表时间：
1972
影响因子：
3.3
通讯作者：
L. J. Thomas
中科院分区：
文献类型：
--
作者：
L. J. Thomas
托马斯，我; J.，Jr.用于选定血液酸碱和血气计算的算法。应用生理学杂志33（I）：154-158。1972.-建议采用最小简化假设的算法，根据红细胞压积、血浆蛋白浓度、血浆pH值、PCO 2和Poe（最后三项在37 ℃下测量）计算血液缓冲液碱、碱过量、氧饱和度和校正至患者温度的Po 2。碱过量的计算值与Siggaard-Andersen（J. Clin. Lab. Invest. 15：21 l-2 17，1963）对准列线图。示出了厌氧温度变化的Po 2校正与在两个广泛不同的温度下测定的全血值相关。的算法的限制和一些可能的简化进行了讨论。血液缓冲液;血碱过多;厌氧温度变化;氧合血红蛋白解离;数字计算机应用用于病人监测和实验室测定的计算机辅助系统（2，6，13，14，16）的广泛使用已经刺激了计算导出的血气和血液酸碱参数的各种方法的发展。这些方法通常采用基于列线图的简化方程或算法来导出期望的参数。各种列线图、计算尺和简化方程很好地将已知的血液物理化学行为定量应用于临床问题。然而，小型通用数字计算机和可编程计算器的能力已经增加到不再需要过分简化的方法的程度。因此，已经尝试收集可用的最可靠的信息，并且在此阐述用于计算一些更有用的参数的合理的不妥协的算法。自变量包括血浆pH、PCOZ、POT、血细胞比容、血浆蛋白浓度、患者温度和任选的氧饱和度。因变量为血液缓冲液碱和碱过量浓度;氧饱和度（如果未给出）;以及根据患者体温校正的pH值、PCO 2、Po 2和氧饱和度。
THOMAS, I;. J., JR. Algorithms for selected blood acid-base and blood gas calculations. J. Appl. Physiol. 33 (I): 154-158. 1972.-Algorithms employing minimal simplifying assumptions are suggested for calculating blood buffer base, base excess, oxygen saturation, and Po2 corrected to patient temperature from hematocrit, plasma protein concentration, plasma pH, PCO 2, and Poe with the last three measured at 37 C. Calculated values for base excess are shown to agree well with the Siggaard-Andersen(J. Clin. Lab. Invest. 15: 21 l-2 17, 1963) alignment nomogram. The Po2 corrections for anaerobic temperature change are shown to correlate well with values determined for whole blood at two widely different temperatures. Limitations and some possible simplifications of the algorithms are discussed. blood buffer base; blood base excess; anaerobic temperature change; oxyhemoglobin dissociation; digital computer applicationsTHE EXPANDING USE of computer-assisted systems (2, 6, 13, 14, 16) for patient monitoring and laboratory determinations has stimulated the development of various approaches to the calculation of derived blood gas and blood acid-base parameters. These approaches commonly employ simplified equations or algorithms based on nomograms to derive the desired parameters. The various nomograms, slide rules, and simplified equations have served well to render practical the quantitative application of what is known of the physicochemical behavior of the blood to clinical problems. However, the capabilities of small general-purpose digital computers and programmable calculators has increased to where excessively simplified approaches are no longer necessary. Thus an attempt has been made to gather the most reliable information available and to set forth here reasonably uncompromising algorithms for calculation of some of the more useful parameters, Independent variables include plasma pH, PCOZ, POT, hematocrit, plasma protein concentration, patient temperature and optionally, oxygen saturation. Dependent variables are blood buffer base and base excess concentrations; oxygen saturation (if not given); and pH, PCO 2, Po2, and oxygen saturation corrected to the patients’ temperature.