High performance liquid chromatographic determination of fluvoxamine in human plasma.
High performance liquid chromatographic determination of fluvoxamine in human plasma.
复制标题
高效液相色谱法测定人血浆中氟伏沙明。
DOI：
--
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
M. Lhermitte
中科院分区：
文献类型：
--
作者：
J. Pommery;M. Lhermitte
建立了人血浆中氟伏沙明的高效液相色谱分离测定方法。该方法以甲氧丙胺为内标，对氟伏沙明的检出限为1.5 ng/m L。当浓度为25 ng/mL时，氟伏沙明的变异系数为+/-5.82，变异系数为100 ng/mL，变异系数为+/-2.78。该方法已用于氟伏沙明治疗患者的血浆分析。
A method has been developed for the separation and measurement of fluvoxamine in human plasma by high performance liquid chromatography. The method uses metapramine as an internal standard and provides a limit of detection of about 1.5 ng/mL for fluvoxamine. At a concentration of 25 ng/mL, fluvoxamine could be measured within a coefficient of variation of +/- 5.82 of the mean and at 100 ng/mL within a CV of +/- 2.78 of the mean. The method has been applied to the analysis of plasma from patients undergoing fluvoxamine therapy.