Analysis of clinical and virological factors associated with response to alpha interferon therapy in chronic hepatitis C
Analysis of clinical and virological factors associated with response to alpha interferon therapy in chronic hepatitis C
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慢性丙型肝炎患者对α干扰素治疗反应相关的临床和病毒学因素分析
DOI：
10.1002/jmv.1890450320
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发表时间：
1995
影响因子：
12.7
通讯作者：
Luigi Barbara
中科院分区：
文献类型：
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作者：
J. Garson;S. Brillanti;K. Whitby;M. Foli;R. Deaville;C. Masci;M. Miglioli;Luigi Barbara
干扰素α（IFN-α）治疗目前是慢性丙型肝炎（HCV）感染的首选治疗方法，但在约75%的治疗患者中未能实现持续反应。决定个体是否对IFN-α有反应的因素是不确定的，尽管已经提出了一些潜在的预测因素。在这项研究中，对30例意大利慢性丙型肝炎患者的临床、人口统计学和病毒学参数与治疗结果的关系进行了评价。所有患者均接受3 MU白细胞来源的IFN-α治疗，每周3次，持续6个月，然后前瞻性随访至少12个月。53%的患者最初有反应，但只有17%的患者观察到持续反应。发现应答者明显比无应答者年轻（45.6 ± 3.1 vs. 55.4 ± 2.7），并且更少发生便秘（2/16 vs. 7/14）。持续应答者的平均治疗前HCV-RNA滴度约为无持续应答者的10倍，但差异无统计学意义。发现HCV基因型与初始和持续应答显著相关。感染HCV-2a的患者比感染HCV-1 B的患者（37%）更有可能应答（89%），并且他们也更有可能维持这种应答（33% vs. 6%）。几何平均滴度在不同基因型之间没有显著差异。© 1995 Wiley利斯公司
Interferon alpha (IFN‐α) therapy is currently the treatment of choice for chronic hepatitis C (HCV) infection, but it fails to achieve a sustained response in approximately 75% of those treated. The factors which determine whether or not an individual will respond to IFN‐α are uncertain, although a number of potentially predictive factors have been proposed. In this study a wide range of clinical, demographic, and virological parameters were evaluated in relation to therapeutic outcome in a group of 30 Italian patients with chronic hepatitis C. All patients received 3 MU leukocyte‐derived IFN‐α three times a week for 6 months and were then followed prospectively for at least 12 months. 53% of patients responded initially, but a sustained response was observed in only 17%. Responders were found to be significantly younger than nonresponders (45.6 ± 3.1 vs. 55.4 ± 2.7), and less frequently cirrhotic (2/16 vs. 7/14). Sustained responders had a mean pretreatment HCV‐RNA titer approximately tenfold lower than that of those who did not have a sustained response, but the difference was not statistically significant. HCV genotype was found to be significantly associated with both initial and sustained response. Patients infected with HCV‐2a were more likely to respond (89%) than those who were infected with HCV‐1 b (37%), and they were also more likely to sustain that response (33% vs. 6%). Geometric mean titers did not vary significantly between the different genotypes. © 1995 Wiley‐Liss, Inc.
G.POZZATO，：“不同的丙型肝炎病毒株与不同严重程度的慢性肝病相关”肝病学。
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