Diversity and dynamism in the cerebellum
Diversity and dynamism in the cerebellum
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DOI：
10.1038/s41593-020-00754-9
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发表时间：
2020-12-07
影响因子：
25
通讯作者：
Raymond, Jennifer L.
中科院分区：
文献类型：
--
作者：
De Zeeuw, Chris I.;Lisberger, Stephen G.;Raymond, Jennifer L.
最近的研究发现了小脑神经元之间的新联系，揭示了大量与奖赏相关的输入，证明了时间信用分配问题的细胞解决方案，并重构了小脑学习理论。历史上被视为一个简单的感觉运动控制器，具有同质结构，小脑越来越多地参与认知功能。它具有令人印象深刻的多样性的分子，细胞和电路机制，嵌入在一个动态的，经常性的电路架构。最近关于小脑的多样性和活力的见解为小脑研究的未来十年提供了路线图，挑战了一些旧概念，重振了其他概念，并定义了主要的新研究方向。
Recent research has discovered new connections between cerebellar neurons, revealed abundant inputs related to reward, demonstrated a cellular solution for the temporal credit assignment problem and restructured theories of cerebellar learning.The past several years have brought revelations and paradigm shifts in research on the cerebellum. Historically viewed as a simple sensorimotor controller with homogeneous architecture, the cerebellum is increasingly implicated in cognitive functions. It possesses an impressive diversity of molecular, cellular and circuit mechanisms, embedded in a dynamic, recurrent circuit architecture. Recent insights about the diversity and dynamism of the cerebellum provide a roadmap for the next decade of cerebellar research, challenging some old concepts, reinvigorating others and defining major new research directions.