Cardiopulmonary effects of sevoflurane, compared with halothane, enflurane, and isoflurane, in dogs.
Cardiopulmonary effects of sevoflurane, compared with halothane, enflurane, and isoflurane, in dogs.
复制标题
与氟烷、安氟烷和异氟烷相比，七氟醚对狗的心肺作用。
DOI：
10.2460/ajvr.1997.58.08.885
复制
发表时间：
1997
影响因子：
1
通讯作者：
Nobuo Sasaki
中科院分区：
文献类型：
--
作者：
T. Mutoh;Ryohei Nishimura;Hwi;S. Matsunaga;Nobuo Sasaki
目的
评价七氟醚（Sevo）与氟烷（Hal）、安氟醚（Enf）和异氟醚（Iso）的心肺效应。
动物
24只健康比格犬，随机分为4组，每组6只犬。
程序
用Sevo、Hal、Enf或Iso麻醉自发通气的犬。在确定每种麻醉剂的最小肺泡浓度（MAC）后，将麻醉维持在轻度（1 MAC）、中度手术（1.5 MAC）和深度（2 MAC），测量清醒状态（基线）和每个麻醉阶段的阶段和心肺变量。
结果
在Sevo组的犬中，心率在所有麻醉阶段均较基线值显著增加。全身血管阻力在Sevo麻醉期间随着麻醉阶段的增加而逐渐降低，伴随着收缩压、平均压和舒张压的剂量依赖性降低。在1.5和2 MAC Sevo时，卒中指数较基线值略有下降，但具有显著性;然而，由于心率显著增加，心脏指数无变化。2 MAC时呼吸频率较1 MAC时显著降低。潮气量和死腔潮气量比在所有麻醉阶段的Sevo不变，导致呼气和肺泡通气量显着减少，在2 MAC，与1和1.5 MAC Sevo的值相比。根据麻醉阶段，PaCO 2升高，pHa显著降低; PaO 2较基线值显著升高，但由于吸入100% O2而保持恒定。
结论
Sevo的心血管效应大于Hal，与Iso相似，小于Enf。在所有麻醉阶段，Sevo的呼吸效应与Iso相似，在2 MAC时大于Hal，在1.5和2 MAC时小于Enf。在中度手术麻醉阶段，Sevo可安全用于进行自主通气的犬。
OBJECTIVE
To evaluate cardiopulmonary effects of sevoflurane (Sevo), compared with halothane (Hal), enflurane (Enf), and isoflurane (Iso).
ANIMALS
24 healthy Beagles, randomly assigned to 4 groups of 6 dogs each.
PROCEDURE
Dogs under spontaneous ventilation were anesthetized with Sevo, Hal, Enf, or Iso. After minimum elveolar concentration (MAC) of each anesthetic was determined, anesthesia was maintained at light (1 MAC), moderate surgical (1.5 MAC), and deep (2 MAC), stages and cardiopulmonary variables at conscious state (baseline) and each anesthesia stage were measured.
RESULTS
In dogs of the Sevo group, heart rate increased significantly from the baseline value at all anesthesia stages. Systemic vascular resistance during Sevo anesthesia decreased gradually with increasing anesthesia stage, which was accompanied by dose-dependent decreases in systolic, mean, and diastolic arterial blood pressures. At 1.5 and 2 MAC Sevo, stroke index decreased slightly but significantly from the baseline value; however, cardiac index was unchanged because of the significant increase in heart rate. Respiratory rate decreased significantly at 2 MAC from that at 1 MAC Sevo. Tidal volume and dead space-to-tidal volume ratio were unchanged at all anesthesia stages of Sevo, resulting in significantly decreased expired and alveolar ventilation at 2 MAC, compared with values at 1 and 1.5 MAC Sevo. PaCO2 increased and pHa decreased significantly, depending on anesthesia stage; PaO2, increased significantly from baseline values, and remained constant because of inhalation of 100% O2.
CONCLUSION
Cardiovascular effects of Sevo were greater than those of Hal, similar to those of Iso, and less than those of Enf. Respiratory effects of Sevo were similar to those of Iso at all anesthesia stages, greater than those of Hal at 2 MAC, and less than those of Enf at 1.5 and 2 MAC. Up to the moderate surgical anesthesia stage, Sevo can be used safely in dogs undergoing spontaneous ventilation.