Role of stromal myofibroblasts infiltrating colon cancer in tumor invasion
Role of stromal myofibroblasts infiltrating colon cancer in tumor invasion
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DOI：
10.1016/s0344-0338(96)80093-8
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发表时间：
1996-07-01
影响因子：
2.8
通讯作者：
Martin, F
中科院分区：
文献类型：
--
作者：
Martin, M;Pujuguet, P;Martin, F
在正常结肠中，肌成纤维细胞与结肠细胞紧密相连，在那里它们沉积 IV 型胶原蛋白，这是主要的基底膜成分。在结肠癌中，这种上皮间质关联被物理破坏，导致产生异常的 IV 型胶原缺陷基底膜。肿瘤浸润肌成纤维细胞是在结直肠癌的侵袭性前沿积聚的迁移细胞。它们产生能够降解肿瘤腺体周围基底膜的裂解酶。它们还参与肿瘤基质细胞外基质成分的合成，从而随后改变上皮结肠癌细胞的粘附和迁移特性。这些结果表明肿瘤浸润肌成纤维细胞在结直肠肿瘤细胞的侵袭和转移中发挥作用。
In the normal colon, myofibroblasts are closely apposed to colonocytes where they deposit type IV collagen, the main basement membrane component. In colon carcinomas, this epithelial-mesenchymal association is physically disrupted, leading to the production of an abnormal, type IV collagen defective, basement membrane. Tumor-infiltrating myofibroblasts are migratory cells that accumulate at the invasive front of the colorectal carcinomas. They produce lytic enzymes able to degrade the basement membrane surrounding tumor glands. They also participate in the synthesis of the extracellular matrix components of the tumor stroma, which could subsequently alter the adhesive and migratory properties of the epithelial colon cancer cells. These results suggest that tumor-infiltrating myofibroblasts play a role in the invasion and metastasis of colorectal tumor cells.