Dielectric metasurface for high-precision detection of large unilamellar vesicles
Dielectric metasurface for high-precision detection of large unilamellar vesicles
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DOI：
10.1088/2040-8986/ac2dd7
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发表时间：
2021-11-01
影响因子：
2.1
通讯作者：
Krauss, T. F.
中科院分区：
文献类型：
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作者：
Conteduca, D.;Quinn, S. D.;Krauss, T. F.
细胞外囊泡（EVs）是一种非常有前途的生物标志物，可用于诊断各种疾病，包括心血管疾病、感染性疾病和神经退行性疾病。特别相关的是它们在癌症液体活检中的重要性，它们在肿瘤的早期发现和监测中起着关键作用。最近已经开发了许多技术来改善当前EV检测方法的性能，但是能够提供高分辨率、高精度和多路复用能力的技术来并行检测几种生物标志物仍然是该领域的一个挑战。在这里，我们展示了检测大型单层囊泡，这是ev的优秀模型，低至浓度
Extracellular vesicles (EVs) are very promising biomarkers for the diagnosis of various diseases, including cardiovascular, infectious and neurodegenerative disorders. Of particular relevance is their importance in cancer liquid biopsy, where they play a key role in the early detection and monitoring of the tumour. A number of technologies have recently been developed to improve the performance of current EV detection methods, but a technique that can provide high resolution, high accuracy and a multiplexing capability for the detection of several biomarkers in parallel remains a challenge in this field. Here, we demonstrate the detection of large unilamellar vesicles, which are excellent models of EVs, down to a concentration