Lacticin Q-Mediated Selective Toxicity Depending on Physicochemical Features of Membrane Components
Lacticin Q-Mediated Selective Toxicity Depending on Physicochemical Features of Membrane Components
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DOI：
10.1128/aac.00808-10
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发表时间：
2011-01
影响因子：
4.9
通讯作者：
F. Yoneyama;K. Ohno;Y. Imura;Mengqi Li;T. Zendo;J. Nakayama;K. Matsuzaki;K. Sonomoto
中科院分区：
文献类型：
--
作者：
F. Yoneyama;K. Ohno;Y. Imura;Mengqi Li;T. Zendo;J. Nakayama;K. Matsuzaki;K. Sonomoto
摘要 Lacticin Q 是一种乳球菌成孔细菌素，对革兰氏阳性菌有活性，但对革兰氏阴性菌没有活性。 Lactin Q 不会诱导革兰氏阴性菌外膜的通透性。使用含有外膜成分的模型膜进行的实验表明，乳酸菌 Q 与革兰氏阴性细菌的外膜结合，但无法穿透它。乳酸菌Q缺乏活性归因于外膜成分的理化特征。
ABSTRACT Lacticin Q, a lactococcal pore-forming bacteriocin, shows activity toward Gram-positive bacteria but not Gram-negative bacteria. Lacticin Q did not induce permeability of the outer membrane of Gram-negative bacteria. Experiments using model membranes containing outer membrane components suggested that lacticin Q binds to the outer membrane of Gram-negative bacteria but is unable to penetrate it. The lack of activity of lacticin Q was attributed to physicochemical features of the outer membrane components.