The bcl-2 oncogene and apoptosis.
The bcl-2 oncogene and apoptosis.
复制标题
bcl-2癌基因和细胞凋亡。
作者：
D. Hockenbery
人类滤泡性淋巴瘤中bcl-2癌基因被激活是t（14;18）染色体易位的结果。Bcl-2在多种体外和体内实验中起抑制细胞凋亡的作用，表明其干扰细胞凋亡的中枢机制。bcl-2蛋白与线粒体内膜相关，但其生化功能尚不清楚。过表达bcl-2的转基因小鼠为bcl-2作为细胞内存活因子在记忆B细胞和胸腺教育中的作用提供了证据。细胞凋亡的其他调节因子，如p53肿瘤抑制基因，可能在人类癌症中作为肿瘤发生的一个步骤而改变。
The bcl-2 oncogene is activated as a consequence of the t(14;18) chromosomal translocation in human follicular lymphomas. Bcl-2 functions to inhibit apoptosis in a variety of in vitro and in vivo experiments, suggesting interference with a central mechanism of apoptosis. The bcl-2 protein is associated with the inner mitochondrial membrane, however, the biochemical function of bcl-2 is unknown. Transgenic mice which overexpress bcl-2 provide evidence for bcl-2's role in memory B cells and thymic education as an intracellular survival factor. Additional regulators of apoptosis, such as the p53 tumor suppressor gene, may be altered in human cancers as one step in tumorigenesis.