Testicular function and sexual activity in senescent mice.
Testicular function and sexual activity in senescent mice.
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衰老小鼠的睾丸功能和性活动。
DOI：
10.1152/ajpendo.1984.247.5.e569
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Desjardins,C
中科院分区：
文献类型：
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作者：
Chubb,C;Desjardins,C
通过测量体外灌注睾丸产生的11种类固醇的分泌率，比较了6月龄和约28月龄CB 6 F1小鼠睾丸的类固醇生成潜力。6月龄和28月龄至30月龄小鼠的睾丸分泌类似数量的睾酮，但发现睾酮生物合成中间产物的分泌存在显着差异。老年小鼠睾丸产生的δ 5-类固醇显著多于年轻雄性小鼠睾丸（P <0.01）。老年雄性小鼠性活动的存在或不存在与睾丸类固醇生成或血浆类固醇水平的变化无关。结果表明，在雄激素生物合成的选择性改变发生在衰老过程中，但在老年小鼠的生殖性能下降是不是由于睾丸类固醇生成的赤字。相反，与年龄相关的性活动减少可能是由中枢神经系统紊乱介导的。
The steroidogenic potentials of testes from 6-mo-old and approximately 28-mo-old CB6F1 mice were compared by measuring the secretion rate of 11 steroids produced by testes perfused in vitro. Testes from 6- and 28- to 30-mo-old mice secreted similar amounts of testosterone, but marked differences in the secretion of testosterone biosynthetic intermediates were discovered. Testes of old mice produced significantly more (P less than 0.01) delta 5-steroids than young male mouse testes. The presence or absence of sexual activity among old male mice was not correlated with changes in testicular steroidogenesis or plasma steroid levels. The results suggest that selected alterations in androgen biosynthesis occur during aging, but that the decline in reproductive performance among old mice is not attributable to deficits in testicular steroidogenesis. Rather, age-associated losses in sexual activity may be mediated by disturbances in the central nervous system.