Climatic Factors and Community - Associated Methicillin-Resistant Staphylococcus aureus Skin and Soft-Tissue Infections - A Time-Series Analysis Study
Climatic Factors and Community - Associated Methicillin-Resistant Staphylococcus aureus Skin and Soft-Tissue Infections - A Time-Series Analysis Study
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DOI：
10.3390/ijerph110908996
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发表时间：
2014-09-01
影响因子：
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通讯作者：
Tamhankar, Ashok J.
中科院分区：
文献类型：
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作者：
Sahoo, Krushna Chandra;Sahoo, Soumyakanta;Tamhankar, Ashok J.
由金黄色葡萄球菌（SA-SSTI）包括耐甲氧西林金黄色葡萄球菌（MRSA）引起的皮肤和软组织感染在世界各地经历了显著的激增。不断变化的气候因素正在影响全球皮肤病感染的负担，目前缺乏关于气候因素与MRSA感染之间关系的信息。因此，在位于印度奥里萨邦布巴内斯瓦尔的一家三级护理医院的门诊部，对温度和相对湿度（RH）与SA-SSTI（n = 387）和MRSA（n = 251）发生的相关性进行了18个月的监测。药敏试验采用纸片扩散法。时间序列分析用于调查气候因素（最高温度、最低温度和相对湿度的周平均值）与SA-SSTI和MRSA感染的周发病率之间的潜在关联。分析表明，每周平均最高温度高于33摄氏度与每周平均相对湿度在55%至78%之间的组合最有利于SA-SSTI和MRSA的发生，并且在这些参数内，MRSA发生率每增加一个单位，每周平均最高气温增加1.7摄氏度（p = 0.044）和每周平均相对湿度增加10%（p = 0.097）。
Skin and soft tissue infections caused by Staphylococcus aureus (SA-SSTIs) including methicillin-resistant Staphylococcus aureus (MRSA) have experienced a significant surge all over the world. Changing climatic factors are affecting the global burden of dermatological infections and there is a lack of information on the association between climatic factors and MRSA infections. Therefore, association of temperature and relative humidity (RH) with occurrence of SA-SSTIs (n = 387) and also MRSA (n = 251) was monitored for 18 months in the outpatient clinic at a tertiary care hospital located in Bhubaneswar, Odisha, India. The Kirby-Bauer disk diffusion method was used for antibiotic susceptibility testing. Time-series analysis was used to investigate the potential association of climatic factors (weekly averages of maximum temperature, minimum temperature and RH) with weekly incidence of SA-SSTIs and MRSA infections. The analysis showed that a combination of weekly average maximum temperature above 33 degrees C coinciding with weekly average RH ranging between 55% and 78%, is most favorable for the occurrence of SA-SSTIs and MRSA and within these parameters, each unit increase in occurrence of MRSA was associated with increase in weekly average maximum temperature of 1.7 degrees C (p = 0.044) and weekly average RH increase of 10% (p = 0.097).