A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system
A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system
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DOI：
10.1109/ispacs.2015.7432786
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发表时间：
2015-11
期刊：
影响因子：
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通讯作者：
M. Kubo;Hiroki Yotsuda;T. Kosaka;N. Nakano
中科院分区：
文献类型：
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作者：
M. Kubo;Hiroki Yotsuda;T. Kosaka;N. Nakano
膜片钳系统通常用于测量通过细胞膜离子通道的离子电流。通过对该系统的集成，实现了高密度的多通道系统。本文设计了用于单通道录音的膜片钳系统中的跨阻放大器。提出的TIA使用OTA（运算跨导放大器）作为反馈电阻，与以前设计的使用多晶硅电阻的TIA相比，TIA的尺寸大大减小。该系统采用0.18μm CMOS工艺制备。设计尺寸为200 μm × 70 μm。仿真和测量结果表明，TIA具有足够的单通道记录性能。通过调节偏置电压，OTA电阻值在5 MΩ ~ 500 MΩ之间变化。带宽至少覆盖10.3 kHz。输入参考噪声的带宽为0.86 pArms，这在片箝法的片上跨阻放大器中是极小的值。TIA功耗为52.3 μW。当电阻值为500MΩ时，输入范围为±50pa。
Patch-clamp system is commonly used to measure ion current flowing through ion channel on cell membrane. By integration of this system, it is realized high density multi-channel system. In this paper, we designed Transimpedance Amplifier (TIA) in a patch-clamp system for single channel recording. Proposed TIA use OTA (Operational Transconductance Amplifier) as a feedback resistor, the size of TIA is drastically decreased compare to previously designed TIA using poly silicon resistor. The system was fabricated using the 0.18μm CMOS process. The designed size is 200 μm by 70 μm. We confirmed by simulation and measurement that the TIA has enough performance for single channel recording. The value of OTA resistance is variable from 5 MΩ to 500 MΩ by adjusting bias voltage. The bandwidth covers at least 10.3 kHz. Input-referred noise is 0.86 pArms in bandwidth that is extremely small value in on-chip transimpedance amplifiers for patch-clamp method. Power consumption of the TIA is 52.3 μW. Input range is ±50 pA when the value of resistance is 500MΩ.