Young inversion with multiple linked QTLs under selection in a hybrid zone.

Young inversion with multiple linked QTLs under selection in a hybrid zone.
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DOI:
10.1038/s41559-017-0119
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发表时间:
2017-04-03
影响因子:
16.8
通讯作者:
Mitchell-Olds T
Mitchell-Olds T
中科院分区:
生物学1区
文献类型:
--
作者:
Lee CR;Wang B;Mojica JP;Mandáková T;Prasad KVSK;Goicoechea JL;Perera N;Hellsten U;Hundley HN;Johnson J;Grimwood J;Barry K;Fairclough S;Jenkins JW;Yu Y;Kudrna D;Zhang J;Talag J;Golser W;Ghattas K;Schranz ME;Wing R;Lysak MA;Schmutz J;Rokhsar DS;Mitchell-Olds T

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固定的染色体倒位可以通过两种方式减少基因流并促进物种形成:抑制重组和在多个位点携带局部有利的等位基因。然而,尚不清楚受青睐的突变是否会在较老的倒位上缓慢积累,或者年轻的倒位是否会因为捕获预先存在的适应性数量性状基因座(QTL)而传播。通过遗传图谱、染色体绘制和基因组测序,我们发现了控制 Boechera stricta 生态重要性状的主要倒位。自末次冰期以来,反转就出现了,随后在混合物种形成区达到了局部高频。此外,反转显示出正向选择的迹象。为了测试倒位是否可以捕获现有的连锁QTL,我们交叉了来自杂交区的标准共线单倍型,并在倒位区域内发现了多个连锁物候QTL。这些发现提供了第一个直接证据,表明在早期物种形成过程中,年轻的倒位可能捕获了相关的、局部适应的 QTL。
Fixed chromosomal inversions can reduce gene flow and promote speciation in two ways: by suppressing recombination and by carrying locally favored alleles at multiple loci. However, it is unknown whether favored mutations slowly accumulate on older inversions or if young inversions spread because they capture preexisting adaptive Quantitative Trait Loci (QTLs). By genetic mapping, chromosome painting and genome sequencing we have identified a major inversion controlling ecologically important traits in Boechera stricta. The inversion arose since the last glaciation and subsequently reached local high frequency in a hybrid speciation zone. Furthermore, the inversion shows signs of positive directional selection. To test whether the inversion could have captured existing, linked QTLs, we crossed standard, collinear haplotypes from the hybrid zone and found multiple linked phenology QTLs within the inversion region. These findings provide the first direct evidence that linked, locally adapted QTLs may be captured by young inversions during incipient speciation.
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