INDIVIDUALIZED TREATMENT FOR ALCOHOL-WITHDRAWAL - A RANDOMIZED DOUBLE-BLIND CONTROLLED TRIAL
INDIVIDUALIZED TREATMENT FOR ALCOHOL-WITHDRAWAL - A RANDOMIZED DOUBLE-BLIND CONTROLLED TRIAL
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DOI：
10.1001/jama.272.7.519
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发表时间：
1994-08-17
影响因子：
120.7
通讯作者：
CALKINS, DR
中科院分区：
文献类型：
--
作者：
SAITZ, R;MAYOSMITH, MF;CALKINS, DR
客观。-评估个体化治疗方案对酒精戒断药物治疗强度和持续时间的影响。随机双盲对照试验。设置。-退伍军人事务部医疗中心的住院戒毒单位。101名患者因酒精戒断治疗而入院，他们可以提供知情同意书，并且没有可能改变戒断临床过程的癫痫发作或药物使用史。患者被随机分配到一个标准的疗程，每天四次，根据需要额外的药物（固定时间表治疗）或治疗方案，提供利血平只有在响应的迹象和症状的发展，酒精戒断（酒精触发治疗）。使用经验证的酒精戒断严重程度的测量方法确定是否需要按需给药。持续时间的药物治疗和总氯氮。与固定方案组的68小时相比，触发方案组的中位治疗持续时间为9小时（P
Objective.-To assess the effect of an individualized treatment regimen on the intensity and duration of medication treatment for alcohol withdrawal.Design.-A randomized double-blind, controlled trial.Setting.-An inpatient detoxification unit in a Veterans Affairs medical center.Patients.-One hundred one patients admitted for the treatment of alcohol withdrawal who could give informed consent and had no history of seizures or medication use that might alter the clinical course of withdrawal.Intervention.-Patients were randomized to either a standard course of chlor-diazepoxide four times daily with additional medication as needed (fixed-schedule therapy) or to a treatment regimen that provided chlordiazepoxide only in response to the development of the signs and symptoms of alcohol withdrawal (symptom-triggered therapy). The need for administration of ''as-needed'' medication was determined using a validated measure of the severity of alcohol withdrawal.Main Outcome Measures.-Duration of medication treatment and total chlor-diazepoxide administered.Results.-The median duration of treatment in the symptom-triggered group was 9 hours compared with 68 hours in the fixed-schedule group (P