Chiropteran influenza viruses: flu from bats or a relic from the past?
Chiropteran influenza viruses: flu from bats or a relic from the past?
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DOI：
10.1016/j.coviro.2016.02.003
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发表时间：
2016-02-01
影响因子：
5.9
通讯作者：
Schwemmle, Martin
中科院分区：
文献类型：
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作者：
Brunotte, Linda;Beer, Martin;Schwemmle, Martin
在蝙蝠身上发现的类似甲型流感的基因组序列表明，南美洲和中美洲存在不同的翼手目流感病毒谱系。这些病毒与传统的甲型流感病毒相似，但缺乏典型的受体结合特性和神经氨酸酶功能。无法分离传染性蝙蝠流感病毒阻碍了进一步的研究，然而，反向遗传分析为这些病毒的分子生物学提供了新的见解。在这篇综述中，我们重点介绍了新发现的蝙蝠衍生的甲型流感病毒领域的最新进展。我们还讨论了蝙蝠是否是被忽视的流感病毒的自然宿主，蝙蝠流感病毒对人类的相关风险，以及这些病毒是否来自禽类IAV池，反之亦然。
The identification of influenza A-like genomic sequences in bats suggests the existence of distinct lineages of chiropteran influenza viruses in South and Central America. These viruses share similarities with conventional influenza A viruses but lack the canonical receptor-binding property and neuraminidase function. The inability to isolate infectious bat influenza viruses impeded further studies, however, reverse genetic analysis provided new insights into the molecular biology of these viruses. In this review, we highlight the recent developments in the field of the newly discovered bat-derived influenza A-like viruses. We also discuss whether bats are a neglected natural reservoir of influenza viruses, the risk associated with bat influenza viruses for humans and whether these viruses originate from the pool of avian IAV or vice versa.