Liquid Chromatographic Behavior of Nitrogen Compounds
Liquid Chromatographic Behavior of Nitrogen Compounds
复制标题
含氮化合物的液相色谱行为
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
J. Hubert
中科院分区：
文献类型：
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作者：
T. Hanai;J. Hubert
摘要氮化合物的色谱行为与其它化合物不同。色谱柱效率较差，有时溶质不能从色谱柱中洗脱出来。因此，测定了烷基胺、苯胺、吡啶、吡嗪、喹啉和氨基多芳烃在pH控制的乙腈/水混合物中在甲基丙烯酸酯凝胶和十八烷基键合硅胶上的洗脱体积。溶剂对解离常数的影响不同于芳香酸的解离常数。在乙腈/水混合物中的值比在100%水中得到的值小。在pH为7的洗脱液中，这些化合物的保留量最大，得到了log P和log k值之间的线性关系。根据这一结果提出了一些疏水碎片常数。在控制pH值的乙腈/水混合物中，十八烷基键合硅胶上的单个基团可以通过对数P值预测这些化合物的保留时间。
Abstract Chromatographic behavior of nitrogen compounds differed from others. The column efficiency was poor for the compounds and sometimes solutes were not eluted out from a column. Therefore, the elution volume of alkylamines, anilines, pyridines, pyrazines, quinolines and aminopolyaromatic hydrocarbons was measured on a methacrylate gel and octadecyl bonded silica gels in pH controlled acetonitrile/water mixtures. The solvent effect on the dissociation constant differs from that obtained for aromatic acids. The values in acetonitrile/water mixtures are smaller than those obtained in 100% water. The linear relation between log P and log k′ values is obtained in eluents of pH 7 where the retention of these compounds is maximized. Some hydrophobic fragmental constants are proposed from this result. Prediction of retention time of these compounds from their log P values can be done in the individual groups on octadecyl bonded silica gels in pH controlled acetonitrile/water mixtures.