Selective progesterone receptor modulators: a class with multiple actions and applications in reproductive endocrinology, and gynecology
Selective progesterone receptor modulators: a class with multiple actions and applications in reproductive endocrinology, and gynecology
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DOI：
10.3109/09513590.2014.950647
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发表时间：
2014-10-01
影响因子：
2
通讯作者：
Bouchard, Philippe
中科院分区：
文献类型：
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作者：
Bouchard, Philippe
在激素依赖性疾病的治疗方面取得了显著的进展，最近选择性类固醇受体调节剂(SPRM)已成为改善多种激素依赖性癌症(乳腺癌、前列腺癌)预后的显著工具。因为它们的显著特性，既有激动性的，也有主要的拮抗性的，来调节孕酮的作用。它们使人们能够更好地了解黄体酮的作用以及在避孕和治疗异常子宫出血以及治疗子宫肌瘤方面的进展。
Among the remarkable progress made in the treatment of hormone-dependent diseases, recently selective steroid receptor modulators (SPRM) have been remarkable tools to improve the prognosis of multiple hormone-dependent cancers (breast, prostate). Because of their remarkable properties, both agonistic and mainly antagonistic, to modulate progesterone action. They have allowed a better understanding of progesterone action and progress in contraception and treatment of abnormal uterine bleeding as well as in the medical treatment of uterine fibroids.