Implantable Biosensors for Real-time Strain and Pressure Monitoring.
Implantable Biosensors for Real-time Strain and Pressure Monitoring.
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DOI：
10.3390/s8106396
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发表时间：
2008-10-15
期刊：
影响因子：
--
通讯作者：
Ong KG
中科院分区：
文献类型：
--
作者：
Tan EL;Pereles BD;Horton B;Shao R;Zourob M;Ong KG
植入式生物传感器是为了实时监测人体内的压力和应变而开发的。传感器是无线的、无源的，由软磁材料和永磁体组成。当暴露在低频交流磁场中时，软磁材料产生的二次磁场也包括更高阶谐振模。感兴趣的参数是通过测量这些高次谐波磁场模式的变化来确定的，这是通过改变永磁体产生的直流磁场的强度来实现的。通过改变软磁材料和永磁体之间的间隔距离来改变直流磁场或偏置磁场。为了监测压力，永久磁铁被放置在密封室的膜上。环境压力的变化使薄膜偏转，改变了两个磁性元件之间的分离距离，从而改变了高次谐波场。同样，在应力/应变传感器中，软磁材料和永磁体由柔性衬底隔开。压力和拉力使衬底发生弯曲，改变了两个单元之间的间隔距离和高次谐场。在本研究中，制作了应力/应变传感器和压力传感器并对其进行了表征。该传感器具有良好的稳定性、线性度和重复性。这种无源和无线传感器技术可用于长期检测人体内的物理量，作为治疗评估、疾病诊断或检测生物医学植入物失败的一部分。
Implantable biosensors were developed for real-time monitoring of pressure and strain in the human body. The sensors, which are wireless and passive, consisted of a soft magnetic material and a permanent magnet. When exposed to a low frequency AC magnetic field, the soft magnetic material generated secondary magnetic fields that also included the higher-order harmonic modes. Parameters of interest were determined by measuring the changes in the pattern of these higher-order harmonic fields, which was achieved by changing the intensity of a DC magnetic field generated by a permanent magnet. The DC magnetic field, or the biasing field, was altered by changing the separation distance between the soft magnetic material and the permanent magnet. For pressure monitoring, the permanent magnet was placed on the membrane of an airtight chamber. Changes in the ambient pressure deflected the membrane, altering the separation distance between the two magnetic elements and thus the higher-order harmonic fields. Similarly, the soft magnetic material and the permanent magnet were separated by a flexible substrate in the stress/strain sensor. Compressive and tensile forces flexed the substrate, changing the separation distance between the two elements and the higher-order harmonic fields. In the current study, both stress/strain and pressure sensors were fabricated and characterized. Good stability, linearity and repeatability of the sensors were demonstrated. This passive and wireless sensor technology may be useful for long term detection of physical quantities within the human body as a part of treatment assessment, disease diagnosis, or detection of biomedical implant failures.
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影响因子：
24
作者：
Aarnoudse, Wilbert;van't Veer, Marcel;van de Vosse, Frans
通讯作者：
van de Vosse, Frans
影响因子：
4.6
作者：
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影响因子：
4.6
作者：
Schnakenberg, U;Kr端ger, C;Schmitz-Rode, T
通讯作者：
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影响因子：
4.6
作者：
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通讯作者：
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影响因子：
4.1
作者：
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通讯作者：
Ong, Keat Ghee