Metastasis from breast carcinoma to a tamoxifen-related endometrial polyp
Metastasis from breast carcinoma to a tamoxifen-related endometrial polyp
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DOI：
10.1016/j.ygyno.2005.03.019
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发表时间：
2005-06-01
影响因子：
4.7
通讯作者：
Cengiz, O
中科院分区：
文献类型：
--
作者：
Acikalin, MF;Öner, Ü;Cengiz, O
背景生殖器外肿瘤转移到子宫内膜息肉是罕见的，迄今为止，仅报道了6例。一位58岁的女性，4年前被诊断为浸润性导管乳腺癌，并接受手术和他莫昔芬治疗，由于在常规腹部超声检查中观察到子宫内膜增厚而住进妇科诊所。全子宫切除术和双侧输卵管卵巢切除术。病理学检查显示一个大息肉，在显微镜下显示息肉基质内有印戒形态的细胞簇。GCDFP-15阳性的肿瘤细胞支持子宫内膜息肉转移性乳腺癌的诊断。转移性乳腺癌应考虑在鉴别诊断癌的印戒细胞形态涉及子宫。(c)2005年爱思唯尔公司All rights reserved.
Background. Metastasis of extragenital neoplasms to an endometrial polyp is rare and until now, only 6 cases of such involvement has been described.Case. A 58-year-old woman, who had been diagnosed 4 years ago with infiltrating ductal breast carcinoma and treated with surgery and tamoxifen therapy, was admitted to the gynecology clinic because of endometrial thickening observed during a routine abdominal ultrasonographic examination. A total hysterectomy with bilateral salpingo-oophorectomy was performed. Pathological examination of the specimen showed a large polyp which microscopically showed clusters of cells with signet ring morphology within the polyp stroma. The positivity of tumor cells for GCDFP-15 supported the diagnosis of metastatic breast carcinoma to endometrial polyp.Conclusion. Metastatic breast carcinoma should be considered in the differential diagnosis of carcinomas with signet ring cell morphology involving uterus. (c) 2005 Elsevier Inc. All rights reserved.