Determination of an Appropriate Cut-Off Value for Ferritin in the Diagnosis of Hemophagocytic Lymphohistiocytosis
Determination of an Appropriate Cut-Off Value for Ferritin in the Diagnosis of Hemophagocytic Lymphohistiocytosis
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DOI：
10.1002/pbc.25058
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发表时间：
2014-11-01
影响因子：
3.2
通讯作者：
Allen, Carl E.
中科院分区：
文献类型：
--
作者：
Lehmberg, Kai;McClain, Kenneth L.;Allen, Carl E.
高铁素血症是噬血细胞性淋巴组织细胞增多症的特征。在HLH-2004标准中，铁蛋白值&500微克/L被认为是阳性。然而，这一水平并不是基于证据确定的。我们比较了123例HLH患者和320例其他高铁蛋白血症患者，计算了受体操作特征，并确定了不同值的敏感度和特异度。当剂量为2,000微克/L时，敏感度为70%，特异度为68%。如果分别分析家族性和病毒相关的获得性HLH，对这一水平的敏感性和特异性是相似的。这一结果可能会指导对当前HLH标准的潜在修改。儿科血癌杂志2014；61：2101-2103。(C)2014年威利期刊公司。
Hyperferritinemia is a hallmark of hemophagocytic lymphohistiocytosis (HLH). In the HLH-2004 criteria, a ferritin value >500 mu g/L is considered positive. However, this level was not determined based on evidence. We compared 123 patients with HLH and 320 patients with other hyperferritinemic conditions, calculated a receiver-operating characteristic, and determined sensitivity and specificity for different values. At 2,000 mu g/L a trade-off is reached with sensitivity at 70% and specificity at 68%. If familial HLH and virus-associated acquired HLH are analyzed separately, sensitivity and specificity are similar for this level. The results may guide a potential modification of the current HLH criteria. Pediatr Blood Cancer 2014;61:2101-2103. (c) 2014 Wiley Periodicals, Inc.