Amine-catalyzed addition of azide ion to α,β-unsaturated carbonyl compounds
Amine-catalyzed addition of azide ion to α,β-unsaturated carbonyl compounds
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DOI：
10.1021/ol9909076
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发表时间：
1999-10-07
期刊：
影响因子：
5.2
通讯作者：
Miller, SJ
中科院分区：
文献类型：
--
作者：
Guerin, DJ;Horstmann, TE;Miller, SJ
[图表]描述了α,β-不饱和羰基化合物的β-叠氮化的新方案，该方法采用叔胺作为叠氮化物加成的催化剂。叠氮化物源是 TMSN3 和 AcOH 的 1:1 混合物。叔胺，无论是在溶液中还是与固体载体结合，都是该反应的有效催化剂。
[GRAPHICS]A new protocol for the beta-azidation of alpha,beta-unsaturated carbonyl compounds is described, The method employs tertiary amines as catalysts for azide addition. The azide source is a 1:1 mixture of TMSN3 and AcOH. Tertiary amines, either in solution or bound to a solid support, are efficient catalysts for the reaction.