Effects of different buffer species on partition coefficients of drugs used in quantitative structure-activity relationships.
Effects of different buffer species on partition coefficients of drugs used in quantitative structure-activity relationships.
复制标题
不同缓冲剂种类对用于定量构效关系的药物分配系数的影响。
DOI：
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
E. Lien
中科院分区：
文献类型：
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作者：
P. H. Wang;E. Lien
A study was conducted in which the same organic solvent, 1-octanol, and different buffer systems were used to obtain intercorrelations among log Pcorr values given by log P (octanol-water) = a log P (octanol-buffer) + b, where a and b are different constants for the different systems used. The range of a was 0.418-1.156 and that of b was -1.962-1.176 for the four buffer systems examined. Only with neutral drugs was the slope (a) close to 1.0 and the intercept (b) close to 0.0 for the three buffer systems studied. For acidic drugs, only 1-octanol-phosphate buffer gave a 1:1 correlation with 1-octanol-water partition coefficients. Acetate and bicarbonate buffer systems gave different correlations. For basic drugs, none of the three systems examined gave a 1:1 correlation with 1-octanol-water partition coefficients.
亲脂性、分子量和药物作用：抛物线和双线性模型的重新检查。
影响因子：
3.8
作者：
Lien,EJ;Wang,PH
通讯作者：
Wang,PH