Impact of acute rejection and early allograft function on renal allograft survival
Impact of acute rejection and early allograft function on renal allograft survival
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DOI：
10.1097/00007890-199706150-00013
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发表时间：
1997-06-15
期刊：
影响因子：
6.2
通讯作者：
Ferguson, RM
中科院分区：
文献类型：
--
作者：
Cosio, FG;Pelletier, RP;Ferguson, RM
移植后早期的急性排斥反应和移植肾的功能与移植肾的长期存活率相关。在这项研究中，我们评估了843名成人首次身体肾移植受者的这两个因素之间的关系，这些受者在一家机构进行了移植，并至少随访了3.5年。根据移植后6个月内有无急性排斥反应(AR)史和移植后6个月血肌酐浓度(Scr6mo<；或≥2 mg/dl)分为4组。无AR和低Scr6mo的患者(组1，n=376)、无AR但Scr6mo升高的患者(组2，n=117)和AR但低Scr6mo的患者(组3，n=185)之间的死亡审查同种异体移植物存活率无显著差异。相反，AR和SCr6mo升高的患者(组4，n=165)的移植物存活率显著低于其他三组患者(COX，P
Both acute rejection and the function of a renal allograft early after transplantation correlate with long-term graft survival. In this study we assessed the relationship between these two factors in 843 adult recipients of first cadaveric renal grafts, transplanted at a single institution and followed for a minimum of 3.5 years. Patients were divided into four groups according to (1) history of acute rejection (AR) during the first 6 months after transplantation, and (2) concentration of serum creatinine at 6 months after transplantation (SCr6mo < or greater than or equal to 2 mg/dl). Death censored allograft survival was not significantly different among patients without AR and with low SCr6mo (group 1, n=376), patients without AR but with an elevated SCr6mo (group 2, n=117), and patients with AR but low SCr6mo (group 3, n=185). In contrast, graft survival was significantly worse in patients with AR and an elevated SCr6mo (group 4, n=165) compared with patients in the other three groups (Cox, P