Correlations between extent of X-ray infiltration and levels of serum C-reactive protein in adult non-severe community-acquired pneumonia
Correlations between extent of X-ray infiltration and levels of serum C-reactive protein in adult non-severe community-acquired pneumonia
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DOI：
10.1016/j.jiac.2015.02.009
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发表时间：
2015-05-01
影响因子：
2.2
通讯作者：
Kohno, Shigeru
中科院分区：
文献类型：
--
作者：
Tamayose, Maki;Fujita, Jiro;Kohno, Shigeru
肺炎病例的严重程度和胸部X光检查结果可能各不相同。C反应蛋白（CRP）水平升高可能是疾病严重程度的指标。我们回顾性地评估了与社区获得性肺炎（CAP）和肺炎球菌性肺炎病例亚组的胸部X线浸润程度相关的因素。在一项评估西他夫利疗效的临床研究中，137名CAP患者先前已入选。在我们的研究中，在这137例CAP患者中确定了75例肺炎球菌肺炎患者。对胸部X线浸润程度进行评分，并采用Logistic回归多因素分析与年龄、性别、体温、白色血细胞（WBC）计数和CRP水平的相关性。在CAP和肺炎球菌性肺炎中，胸部X线浸润程度与CRP水平之间存在显著相关性。我们的数据表明，CRP是一个有价值的信息资源，可以反映肺炎的严重程度的情况下，CAP和肺炎球菌肺炎。(C)2015年，日本化疗学会和日本传染病协会。由爱思唯尔有限公司出版。保留所有权利。
Pneumonia cases can vary in both severity and chest X-ray findings. Elevated C-reactive protein (CRP) levels may be an indicator of disease severity. We retrospectively evaluated factors correlated with the extent of chest X-ray infiltration both in community-acquired pneumonia (CAP) and a subgroup of cases with pneumococcal pneumonia. In a clinical study that evaluated the efficacy of sitafloxacin, 137 patients with CAP had been previously enrolled. In our study, 75 patients with pneumococcal pneumonia were identified among these 137 CAP patients. The extent of chest X-ray infiltration was scored and correlations with age, sex, body temperature, white blood cell (WBC) count, and CRP levels were analyzed using multivariate analysis with logistic regression. Significant correlations were observed between the extent of chest X-ray infiltration and CRP levels in both CAP and pneumococcal pneumonia. Our data indicates that CRP is a valuable and informative resource that could reflect the severity of pneumonia in cases of both CAP and pneumococcal pneumonia. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.