Alcohol consumption and all-cause mortality among elderly in Finland
Alcohol consumption and all-cause mortality among elderly in Finland
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DOI：
10.1016/j.drugalcdep.2009.08.017
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发表时间：
2010-01-15
影响因子：
4.2
通讯作者：
Aalto, Mauri
中科院分区：
文献类型：
--
作者：
Halme, Jukka T.;Seppa, Kaija;Aalto, Mauri
目的：估计老年男性中特定性别的饮酒水平流行率，并调查酗酒与全因死亡率之间的关联。设计：对来自年龄 > 65 岁的芬兰全国代表性样本的队列进行了六年的跟踪调查。受试者人数为 1569 人（原始样本的 72.7%，女性 65.3%，加权 n = 1357）。 测量：通过 12 个月内特定饮料的数量和频率来回顾性测量酒精消耗量。死亡率数据来自官方死因登记册。使用 Cox 比例风险模型分析死亡的相对风险 (RR)。研究结果：重度饮酒（每周超过 8 标准杯）的患病率男性为 20.3%，女性为 1.2%。超过十分之一 (11.4%) 的男性表示每周饮酒 5 标准杯。相对死亡风险表明饮酒水平与死亡率之间存在 J 曲线关系。然而，当使用饮酒量作为连续变量时，没有发现显着的曲线关系。与戒酒者相比，中度饮酒者（每周 1-7 杯）死亡的多变量调整 RR 为 0.41 (95% CI=.23-.72)。与不饮酒的男性相比，每周饮酒量 >= 15 标准杯的男性的多变量调整后死亡风险是前者的两倍（RR = 2.11，95% CI = 1.19-3.75）。女性的饮酒水平太低，无法进行分析。结论：大量饮酒在芬兰老年男性中很常见，但在女性中并不常见。本研究表明，平均每天饮酒超过两标准杯的男性，全因死亡风险会增加。 (c) 2009 Elsevier Ireland Ltd. 保留所有权利。
Aims: To estimate the gender-specific prevalences of alcohol consumption levels and to investigate the association between heavy drinking and all-cause mortality among elderly males.Design: A cohort derived from a nationally representative sample of Finns aged >65 years was followed for six years. Number of subjects was 1569 (72.7% of the original sample, 65.3% females, weighted n = 1357).Measurements: Alcohol consumption was retrospectively measured by beverage-specific quantity and frequency over a 12-month period. Mortality data were obtained from the official Cause-of-Death Register. Cox proportional hazards models were used to analyse the relative risks (RRs) of death.Findings: The prevalence of heavy drinking (>8 standard drinks per week) was 20.3% in males and 1.2% in females. Over one-tenth (11.4%) of males reported drinking :l 5 standard drinks per week. Relative death risks suggested a J-curved relationship between alcohol consumption levels and mortality. However, significant curvilinear relationship was not found, when using alcohol consumption as continuous variable. The multivariate adjusted RR of death among moderate drinkers (1-7 drinks per week) vs. abstinent subjects was 0.41 (95% CI=.23-.72). Males drinking >= 15 standard drinks per week had a two-fold multivariate adjusted risk of death (RR = 2.11, 95% CI = 1.19-3.75) compared with abstinent males. The level of alcohol consumption by females was too low for analysis.Conclusions: Heavy drinking is common among Finnish elderly males but not among females. The present study shows an increased all-cause mortality risk for males drinking, on average, more than two standard drinks per day. (c) 2009 Elsevier Ireland Ltd. All rights reserved.