Segmental Duplications Contribute to Gene Expression Differences Between Humans and Chimpanzees
Segmental Duplications Contribute to Gene Expression Differences Between Humans and Chimpanzees
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DOI：
10.1534/genetics.108.099960
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发表时间：
2009-06-01
期刊：
影响因子：
3.3
通讯作者：
Gilad, Yoav
中科院分区：
文献类型：
--
作者：
Blekhman, Ran;Oshlack, Alicia;Gilad, Yoav
除了顺式和反式调控元件的特定变化之外，据推测基因组的结构变化是物种间基因表达大量差异的基础。因此，我们表明物种特异性的片段重复富含在人类和黑猩猩之间差异表达的基因。
In addition to specific changes in cis-and trans-regulatory elements us, structural changes in the genome are hypothesized to underlie a large number of differences in gene expression between species. Accordingly, we show that species-specific segmental duplications are enriched with genes that are differentially expressed between humans and chimpanzees.