Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders.
Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders.
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DOI：
10.2741/pletnik
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发表时间：
2002-03
期刊：
影响因子：
--
通讯作者：
M. Pletnikov;T. Moran;K. Carbone
中科院分区：
文献类型：
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作者：
M. Pletnikov;T. Moran;K. Carbone
自闭症谱系障碍（ASD）一直是大量研究和临床推测的焦点。这种强烈的兴趣与这些疾病的复杂发病机制和破坏性后果有关。理解自闭症的发病机制及其有效治疗的障碍之一是缺乏可用于异常大脑和行为发育的假设驱动机制研究以及用于临床前测试新药物治疗的动物模型。本文对一种新的ASD动物模型进行了详细的分析。该模型利用新生儿博尔纳病病毒（BDV）感染大鼠大脑作为独特的实验致畸剂来研究神经发育损伤的发病机制。十多年来，对BDV动物模型的研究已经对大鼠异常脑发育和导致的自闭症样行为异常的致病过程产生了很大的了解。最近的实验表明，BDV模型的效用，用于研究的基因-环境相互作用，确定不同的疾病结果和治疗反应的变异性的病理生理机制。
Autism spectrum disorders (ASD) have been the focus of a great deal of research and clinical speculation. This intense interest relates to both the perplexing pathogenesis and devastating consequences of these disorders. One of the obstacles to understanding the pathogenesis of autism and its efficient treatment has been the paucity of animal models that could be used for hypotheses-driven mechanistic studies of abnormal brain and behavior development and for the pre-clinical testing novel pharmacological treatments. The present review provides a detailed analysis of a new animal model of ASD. This model utilizes neonatal Borna disease virus (BDV) infection of the rat brain as a unique experimental teratogen to study the pathogenesis of neurodevelopmental damage. For more than a decade, studies of the BDV animal model have yielded much insight into the pathogenic processes of abnormal brain development and resulting autistic-like behavioral abnormalities in rats. The most recent experiments demonstrate the utility of the BDV model for studying the pathophysiological mechanisms of the gene-environment interaction that determines differential disease outcomes and variability in responses to treatments.